EXCIPIENT SYSTEM FOR TOPICAL DELIVERY OF PHARMACEUTICAL AGENTS

• US 20140010902A1
• Filed: 09/10/2013
• Published: 01/09/2014
• Est. Priority Date: 09/10/2012
• Status: Abandoned Application

• Current Assignee: AD Lunam Labs, Inc.
• Original Assignee: AD Lunam Labs
• Inventors: Beeson, William H., Rockhill, Turner
• Application Number:
  US14/022,403
• Publication Number:
  US 20140010902A1
• Time in Patent Office: Days
• US Class Current: 424/745
• CPC Class Codes: A61K 31/07 Retinol compounds, e.g. vitamin A retinoic acids A61K31/203
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/506 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/53 Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 38/18 Growth factors; Growth regulators
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/46 Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The subject invention is based upon the discovery that a wide variety of pharmaceutical agents can be delivered into the skin, fingernails, and toenails of patients by dissolving or dispersing the pharmaceutical agent in a solvent system which is comprised of a combination of an alkyl lactate and Simmondsia chinesis seed oil. The subject invention more specifically discloses a pharmaceutical serum which is comprised of (1) an alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, (2) Simmondsia chinesis seed oil, and (3) a pharmaceutical agent. Some representative examples of pharmaceutical agent which can be incorporated into the pharmaceutical serums of this invention include, hormones, growth factors (cytokines), antimicrobials, antibacterials, antibiotics, non-steroidal anti-inflammatory agents, immunodilators, anesthetics, plant extracts, vitamins, corticosteroids, hair growth stimulants, and the like.

Claims

1. A pharmaceutical serum which is comprised of (1) an alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, (2) Simmondsia chinesis seed oil, and (3) a pharmaceutical agent.

2. A pharmaceutical serum as specified in claim 1 wherein the alkyl lactate contains from 4 to 6 carbon atoms.

3. A pharmaceutical serum as specified in claim 1 wherein the alkyl lactate is isoamyl lactate.

4. A pharmaceutical serum as specified in claim 3 wherein the Simmondsia chinesis seed oil is golden Simmondsia chinesis seed oil.

5. A pharmaceutical serum as specified in claim 3 wherein the Simmondsia chinesis seed oil is filtered.

6. A pharmaceutical serum as specified in claim 3 wherein the Simmondsia chinesis seed oil is refined.

7. A pharmaceutical serum as specified in claim 3 wherein the alkyl lactate is present at a level which is within the range of about 5 weight percent to about 90 weight percent, wherein the Simmondsia chinesis seed oil is present at a level of about 5 weight percent to about 90 percent, and wherein the pharmaceutical agent is present at a level of about 0.01 weight percent to about 40 weight percent.

8. A pharmaceutical serum as specified in claim 7 wherein the antifungal serum is further comprised of at least one additional oil.

9. A pharmaceutical serum as specified in claim 8 wherein the additional oil is a vegetable oil.

10. A pharmaceutical serum as specified in claim 1 wherein the pharmaceutical agent is a hair growth stimulant.

11. A pharmaceutical serum as specified in claim 10 wherein the hair growth stimulant is an antihypertensive vasodilators or minoxidil.

12. A pharmaceutical serum as specified in any of claim 11 wherein the hair growth stimulant is present at a level which is within the range of about 0.5 weight percent to about 12 weight percent.

13. A method for treating hair loss which comprised topically applying a hair growth serum to an area of skin where hair growth is desired, wherein the hair growth serum is the pharmaceutical serum specified in claim 12.

19. A pharmaceutical serum as specified in claim 1 wherein the pharmaceutical agent is selected from the group consisting of hormones, antimicrobials, antibacterials, antibiotics, non-steroidal anti-inflammatory agents, immunodilators, anesthetics, plant extracts, vitamins, vitamin derivatives, and corticosteroids.

20. A pharmaceutical serum as specified in claim 1 wherein the pharmaceutical agent is a growth factor.

14. A skin rejuvenation serum which is comprised of (1) an alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, (2) Simmondsia chinesis seed oil, and (3) an from extract a Libiatae plant.

15. A skin rejuvenation serum as specified in claim 14 wherein the alkyl lactate is isoamyl lactate, and wherein the extract from the Libiatae plant is rosemary extract or marjoram extract.

16. A skin rejuvenation serum which is comprised of (1) an alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, (2) Simmondsia chinesis seed oil, and (3) a vitamin A derivative selected from the group consisting of retinol and retinoic acid.

17. A skin rejuvenation serum as specified in claim 16 wherein the vitamin A derivative is retinol, and wherein the retinol is present at a level which is within the range of about 0.1 weight percent to about 15 weight percent, based upon the total weight of the skin rejuvenation serum.

18. A skin rejuvenation serum as specified in claim 16 wherein the vitamin A derivative is retinoic acid and wherein the retinoic acid is present at a level which is within the range of about 0.005 weight percent to about 0.5 weight percent, based upon the total weight of the skin rejuvenation serum.