SMALL MOLECULES AS EPIGENETIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS
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Accused Products
Abstract
The invention provides for novel compounds which are inhibitors of lysine-specific demethylase 1 (LSD1). Such compounds may be used to treat disorders, including cancer.
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Citations
60 Claims
- 1. A compound of formula II,
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14. (canceled)
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16-18. -18. (canceled)
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21. (canceled)
- 22. A method of treating a disease or disorder associated with lysine-specific demethylase 1 (LSD1) in a subject, the method comprising the step of administering to the subject an effective amount of a compound of formula I, formula II, or formula III,
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23. A method of treating a disease or disorder associated with lysine-specific demethylase 1 (LSD1) in a subject, wherein the subject is identified as being in need of a LSD1 inhibitor, the method comprising the step of administering to the subject an effective amount of a compound of formula I, formula II, or formula III,
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25-28. -28. (canceled)
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29. A method of inhibiting or reducing lysine-specific demethylase 1 (LSD1) in a subject, the method comprising the step of administering to the subject an effective amount of a compound of formula I, formula II, or formula III,
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30-31. -31. (canceled)
- 32. A method of treating tumor, cancer, blood disorder or neoplasia in a subject, the method comprising the step of administering to the subject an effective amount of a compound of formula I, formula II, or formula III,
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34-59. -59. (canceled)
Specification