DEVICE AND METHOD FOR REMOVAL OF BLOOD-BORNE PATHOGENS, TOXINS AND INFLAMMATORY CYTOKINES
First Claim
1. A system for broad-spectrum whole-blood separation of blood-borne factors of interest comprising:
- a solid substrate or cartridge and a biosensor.
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Accused Products
Abstract
The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.
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Citations
22 Claims
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1. A system for broad-spectrum whole-blood separation of blood-borne factors of interest comprising:
- a solid substrate or cartridge and a biosensor.
- View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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2. A system for broad-spectrum whole-blood separation of blood-borne factors of interest comprising:
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a broad-spectrum, anti-thrombogenic cartridge a biosensor a pump, and a patient monitor.
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16. A method for broad-spectrum whole-blood separation of blood-borne factors comprising:
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(a) detecting the presence or amount of a blood-borne factor of interest using a biosensor, (b) bringing a sample of blood in contact with a broad-spectrum, anti-thrombogenic cartridge, and (c) separating the sample from said broad-spectrum, anti-thrombogenic cartridge whereby said blood-borne factor is at least partially retained on said cartridge and the removed sample has a reduced amount of blood-borne factor. - View Dependent Claims (17, 18, 19, 20, 21)
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22. A method for treating a patient suspected of having sepsis comprising:
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(a) detecting the presence or an increase in at least one biomarker, (b) contacting a sample of blood with a broad-spectrum, anti-thrombogenic cartridge, and (c) separating the sample from said broad-spectrum, anti-thrombogenic cartridge whereby one or more blood-borne factors of interest is at least partially retained on said cartridge and the removed sample has a reduced amount of blood-borne factor(s).
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Specification