Monitoring of Fluid Content
First Claim
1. An apparatus, comprising:
- a multilayer structure comprising;
(i) a first electrode layer comprising a first electrode and a first material,(ii) a second electrode layer comprising a second electrode, and(iii) an insulating layer positioned between the first electrode layer and the second electrode layer; and
a flow channel configured to receive a substantially continuous flow of fluid, wherein each of the first material and the second electrode layer form a portion of a sidewall of the flow channel.
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Abstract
This application describes methods and apparatus for monitoring of fluid content that are suitable for in-situ, real time and/or continuous monitoring, especially of bodily fluids and in particular the content of sweat. The application also describes fabrication of such an apparatus. The apparatus comprises a multilayer structure comprising at least two electrode layers for detection of fluid content separated by at least one insulating layer. The multilayer structure defines at least one flow channel which provides a flow path for continuous flow of fluid in use, and the electrode layers form part of the sidewall of the flow channel(s). The flow channel(s) may run in a direction substantially perpendicular to the layers. The electrode layers may employ electrochemical detection and may comprise a reference electrode and an ion-sensitive electrode. The apparatus may be fabricated using various printing or deposition techniques.
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Citations
20 Claims
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1. An apparatus, comprising:
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a multilayer structure comprising; (i) a first electrode layer comprising a first electrode and a first material, (ii) a second electrode layer comprising a second electrode, and (iii) an insulating layer positioned between the first electrode layer and the second electrode layer; and a flow channel configured to receive a substantially continuous flow of fluid, wherein each of the first material and the second electrode layer form a portion of a sidewall of the flow channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. An apparatus, comprising:
a multilayer structure comprising a plurality of flow channels configured to receive a substantially continuous flow of fluid, wherein a sidewall of each flow channel is formed by; (i) a first electrode layer comprising a first electrode and a first material, wherein the first material forms the sidewall; (ii) a second electrode layer comprising a second electrode; and (iii) an insulating layer positioned between the first electrode layer and the second electrode layer. - View Dependent Claims (16, 17)
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18. A method, comprising:
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providing a monitoring apparatus comprising; (i) a first electrode layer comprising a first electrode and a first material, (ii) a second electrode layer comprising a second electrode, and (iii) an insulating layer positioned between the first electrode layer and the second electrode layer; and a flow channel configured to receive a substantially continuous flow of fluid, wherein each of the first material and the second electrode layer form a portion of a sidewall of the flow channel; inducing the substantially continuous flow of fluid; measuring a voltage difference between the first electrode and the second electrode; and based on the voltage difference, determining a concentration of at least one analyte in the fluid. - View Dependent Claims (19, 20)
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Specification