COMPUTER-ASSISTED KARYOTYPING
First Claim
1. A method for computer-assisted karyotyping, comprising:
- inputting a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises;
a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images;
a bend correcting function adapted to straightening images of chromosomes that are bent or curved;
a feature selection function adapted for distinguishing between chromosome bands;
wherein the classifier module generates a classification of the image as normal or abnormal and generates an output therefrom.
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Abstract
A system and method for computer-assisted karyotyping includes a processor which receives a digitized image of metaphase chromosomes for processing in an image processing module and a classifier module. The image processing module may include a segmenting function for extracting individual chromosome images, a bend correcting function for straightening images of chromosomes that are bent or curved and a feature selection function for distinguishing between chromosome bands. The classifier module, which may be one or more trained kernel-based learning machines, receives the processed image and generates a classification of the image as normal or abnormal.
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Citations
25 Claims
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1. A method for computer-assisted karyotyping, comprising:
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inputting a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises; a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images; a bend correcting function adapted to straightening images of chromosomes that are bent or curved; a feature selection function adapted for distinguishing between chromosome bands; wherein the classifier module generates a classification of the image as normal or abnormal and generates an output therefrom. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A system for computer-assisted karyotyping, comprising:
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a data storage device for receiving and storing digitized images of metaphase chromosomes; a processor in communication with the data storage device comprising an image processing module and a classifier module, wherein the image processing module comprises; a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images; a bend correcting function adapted to straightening images of chromosomes that are bent or curved; a feature selection function adapted for distinguishing between chromosome bands; an output device in communication with the processor for displaying an output comprising a classification of the image as normal or abnormal. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 21)
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18. A non-transitory machine-readable medium comprising a plurality of instructions that, in response to being executed, result in a computing system executing an automated karyotyping process, comprising:
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receiving a digitized image of metaphase chromosomes into a processor comprising an image processing module and a classifier module, wherein the image processing module comprises; a segmenting function adapted for segmenting the digitized image for extracting individual chromosome images; a bend correcting function adapted to straightening images of chromosomes that are bent or curved; a feature selection function adapted for distinguishing between chromosome bands; classifying the processed image from the image processing module to separate normal and abnormal; and outputting a report to a display device, the report comprising a classification of the image as normal or abnormal. - View Dependent Claims (19, 20, 22, 23, 24, 25)
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Specification