Method for treament of neurologic dysfunction

• US 20140018382A1
• Filed: 05/14/2013
• Published: 01/16/2014
• Est. Priority Date: 09/20/2004
• Status: Active Grant

• Current Assignee: Meddev, Inc.
• Original Assignee: Meddev, Inc.
• Inventors: DeLack, Elaine A.
• Granted Patent: US 9,364,474 B2
• Time in Patent Office: Days
• US Class Current: 514/280
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/44 Non condensed pyridines; Hydrogenated derivatives thereof
• CPC Class Codes: A61K 31/475 having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine vincamine A61K31/4375
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/7015 Drug-containing film-forming compositions, e.g. spray-on
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: C07D 471/14 Ortho-condensed systems

Abstract

A method for treatment of the symptoms of neurologic dysfunctions, including major depression, an autism spectrum disorder (ASD), and schizophrenia. The patient is administered an amount of a compound that increases the catalytic activity of MAO-A.

The effective compound is preferably reserpine, administered in a dosage of less than about 0.03 mg per day. The reserpine may be administered topically or transdermally at a dosage in the range from about 0.002 mg per day to about 0.02 mg per day. In homeopathic use, the reserpine may be administered in the form of a homeopathic dilution, preferably as a 12 C homeopathic dilution of reserpine.

Claims

1. A method for treatment of the symptoms of an autism spectrum disorder, comprising;

administering to a patient a daily dosage of a homeopathic dilution of reserpine.

2. The method of claim 1, wherein the step of administering to a patient a daily dosage of a homeopathic dilution of reserpine comprises:

administering said daily dosage of a homeopathic dilution of reserpine by transdermal application.

3. The method of claim 1, wherein the step of administering to a patient a daily dosage of a homeopathic dilution of reserpine comprises:

administering to a patient a 12 C homeopathic dilution of reserpine.

4. The method of claim 1, wherein the step of administering to a patient a daily dosage of a homeopathic dilution of reserpine comprises:

administering to a patient a daily dosage of a homeopathic dilution of reserpine having reserpine as a sole active ingredient.

5. A method for treatment of the symptoms of an autism spectrum disorder, comprising:

transdermally administering to a patient a daily dose of a 12 C homeopathic dilution of reserpine, said homeopathic dilution of reserpine having reserpine as a sole active ingredient.