BLOOD COMPONENT MEASURING DEVICE

• US 20140024904A1
• Filed: 09/24/2013
• Published: 01/23/2014
• Est. Priority Date: 03/31/2011
• Status: Abandoned Application

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: TAKINAMI, Masao
• Application Number:
  US14/035,072
• Publication Number:
  US 20140024904A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1491 Heated applicators
• CPC Class Codes: A61B 5/489 Blood vessels
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: G01N 21/314 with comparison of measurements at specific and non-specific wavelengths dual wavelength spectrometry G01J3/427
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A blood component measuring device includes an irradiation light source configured to emit light at least in a near-infrared region, a light receiver having such sensitivity as to receive light emitted by the irradiation light source, a holding mechanism that holds and fixes a living body part, and an arithmetic device that calculates the concentration of a blood component in the living body part. The calculating means calculates the concentration of the blood component about, of the living body part, a place where the ratio of transmitted light intensity at a first wavelength relatively easily absorbed by hemoglobin and transmitted light intensity at a second wavelength relatively poorly absorbed by hemoglobin is the minimum.

Claims

1. A blood component measuring device that irradiates a living body part with light and measures a blood component of the living body part, the blood component measuring device comprising:

a holding mechanism that holds and fixes a position of the living body part;

at least one irradiation light source which emits at different times;

i) light at a first wavelength which is directed toward the living body part when the living body part is held in the holding mechanism;

ii) light at a second wavelength which is directed toward the living body part when the living body part is held in the holding mechanism; and

iii) light in a near-infrared region which is directed toward the living body part when the living body part is held in the holding mechanism, the light at the first wavelength being relatively easily absorbed by hemoglobin while the light at the second wavelength is relatively poorly absorbed by hemoglobin;

a light receiver which receives the light emitted by the irradiation light source;

an intensity calculator calculating a transmitted light intensity S1 at the first wavelength based on output from the light receiver and calculating a transmitted light intensity S2 at the second wavelength based on output from the light receiver;

a measurement site extractor which identifies as a measurement site a location on the living body part at which a ratio S1/S2 is a minimum; and

calculating means for calculating a concentration of the blood component at the measurement site of the living body part.

2. The blood component measuring device according to claim 1, wherein the light receiver is a light receiving element array in which a plurality of light receiving elements are arranged in a matrix.

3. The blood component measuring device according to claim 2, wherein the calculating means calculates the concentration of the blood component at one of the light receiving elements, from amongst the plurality of light receiving elements forming the light receiving element array.

4. The blood component measuring device according to claim 1, further comprising a scanner mechanism, positioned between the at least one irradiation light source and the holding mechanism, that reflects light from the irradiation light source and scans the living body part with the light along an optical path between the irradiation light source and the holding mechanism.

5. The blood component measuring device according to claim 4, wherein the light receiver receives the transmitted light with the first wavelength and transmitted light with the second wavelength at a plurality of places of the living body part by scanning of the light by the scanner mechanism.

6. The blood component measuring device according to claim 1, wherein the calculating means includes:

a first extractor that extracts, as a first measurement site, the location on the living body at which the ratio (S1/S2) is the minimum;

a second extractor that extracts, as a second measurement site, a place on the living body at which the ratio (S1/S2) is a maximum among sites where the transmitted light intensity S2 at the second wavelength is substantially equal to the transmitted light intensity S1 of the first measurement site;

a first transmission spectrum generator that generates a transmission spectrum of the first measurement site;

a second transmission spectrum generator that generates a transmission spectrum of the second measurement site;

a differential transmission spectrum calculator that calculates a differential transmission spectrum between the first measurement site and the second measurement site from the transmission spectrum of the first measurement site and the transmission spectrum of the second measurement site; and

a concentration calculator that calculates the concentration of the blood component based on the differential transmission spectrum.

7. The blood component measuring device according to claim 1, further comprising a warming mechanism that warms the living body part.

8. A blood component measuring device that irradiates a living body part with light and measures a blood component of the living body part, the blood component measuring device comprising an irradiation light source which emits light at least in a near-infrared region;

a light receiver having sensitivity to receive light emitted by the irradiation light source;

a holding mechanism that holds and fixes a position of the living body part;

calculating means for calculating a concentration of the blood component in the living body part;

the calculating means calculating the concentration of the blood component at a location of the living body part in which a ratio S1/S2 of transmitted light intensity S1 at a first wavelength which is relatively easily absorbed by hemoglobin and transmitted light intensity S2 at a second wavelength which is different from the first wavelength and which is relatively poorly absorbed by hemoglobin is a minimum.

9. The blood component measuring device according to claim 8, wherein the light receiver is a light receiving element array in which light receiving elements are arranged in a matrix, and the calculating means calculating means calculates the concentration of the blood component at one of the light receiving elements, from amongst the plurality of light receiving elements forming the light receiving element array.

10. The blood component measuring device according to claim 8, further comprising a scanner mechanism, positioned between the at least one irradiation light source and the holding mechanism, that reflects light from the irradiation light source and scans the living body part with the light along an optical path between the irradiation light source and the holding mechanism;

wherein the light receiver receives, at a plurality of places of the living body part, both the transmitted light at the first wavelength and the transmitted light at the second wavelength through scanning of the light as a result of operation of the scanner mechanism; and

wherein the calculating means calculates the concentration of the blood component at the place of the living body part which is irradiated with light at the first wavelength and light at the second wavelength where the ratio of the transmitted light intensity S1 at the first wavelength and the transmitted light intensity S2 at the second wavelength is the minimum.

11. The blood component measuring device according to claim 8, wherein the calculating means includes:

a first extractor that extracts, as a first measurement site, the location on the living body at which the ratio (S1/S2) is the minimum;

a second extractor that extracts, as a second measurement site, a place on the living body at which the ratio (S1/S2) is a maximum among sites where the transmitted light intensity S2 at the second wavelength is substantially equal to the transmitted light intensity S1 of the first measurement site;

a first transmission spectrum generator that generates a transmission spectrum of the first measurement site;

a second transmission spectrum generator that generates a transmission spectrum of the second measurement site;

a differential transmission spectrum calculator that calculates a differential transmission spectrum between the first measurement site and the second measurement site from the transmission spectrum of the first measurement site and the transmission spectrum of the second measurement site; and

a concentration calculator that calculates the concentration of the blood component based on the differential transmission spectrum.

12. The blood component measuring device according to claim 8, further comprising a warming mechanism that warms the living body part.

13. A method of measuring a blood component of a living body part comprising:

emitting, at a plurality of locations on the living body, light possessing a first wavelength which is relatively easily absorbed by hemoglobin;

emitting, at the plurality of locations on the living body, light possessing a second wavelength which is relatively poorly absorbed by hemoglobin;

calculating a light intensity S1 of the light possessing the first wavelength which has passed through the living body at the plurality of locations on the living body;

calculating a light intensity S2 of the light possessing the second wavelength which has passed through the living body at the plurality of locations on the living body;

determining as a measurement site the location on the living body part at which a ratio S1/S2 is a minimum;

emitting light in a near-infrared region at the measurement site and receiving the light in the near-infrared region that has passed through the calculating means for calculating a concentration of the blood component at the measurement site of the living body part; and

measuring the blood component of the living body part based on the light in the near-infrared region that has passed through the living body part at the measurement site.

14. The method according to claim 13, further comprising warming the living part before emitting the light possessing the first wavelength and before emitting the light possessing the second wavelength.