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CHIP SET-UP AND HIGH-ACCURACY NUCLEIC ACID SEQUENCING

  • US 20140034497A1
  • Filed: 06/14/2013
  • Published: 02/06/2014
  • Est. Priority Date: 06/15/2012
  • Status: Active Grant
First Claim
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1. A method for nucleic acid sequencing, comprising:

  • (a) providing a chip comprising a plurality of discrete sites at a density greater than or equal to about 500 sites per 1 mm2, wherein an individual site of said plurality of discrete sites comprises at least one nanopore formed in a membrane disposed adjacent to an electrode, wherein each discrete site is adapted to aid in the detection of said nucleic acid molecule or a portion thereof;

    (b) directing a plurality of nucleic acid molecules to said plurality of discrete sites; and

    (c) characterizing, with the aid of a computer processor coupled to said discrete sites, a nucleic acid sequence of each of said nucleic molecules based on electrical signals received from said plurality of discrete sites.

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