METHOD OF PRODUCING SUBSTANCES WITH SUPERSATURATED GAS, TRANSDERMAL DELIVERY DEVICE THEREOF, AND USES THEREOF

• US 20140044805A1
• Filed: 04/19/2012
• Published: 02/13/2014
• Est. Priority Date: 01/27/2012
• Status: Active Grant

• Current Assignee: Invisiderm, LLC
• Original Assignee: Invisiderm, LLC
• Inventors: Kiss, Norbert
• Granted Patent: US 10,130,800 B2
• Time in Patent Office: Days
• US Class Current: 424/700
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 35/30 Gas therapy for therapeutic treatment of the skin
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04

Abstract

The present specification disclosed a noninvasive transdermal delivery device that relates generally to a handheld mechanical apparatus for noninvasive transdermal administration of gas, small to large water-soluble (hydrophilic) pharmaceutical agents, vitamins, and other therapeutic agents. Components of such delivery devices, methods of producing a substance comprising a supersaturated amount of a dissolved gas, as well as, methods of administering a therapeutic agent using such delivery devices and methods of treating a disease or condition using such delivery devices are also disclosed.

Claims

1-35. -35. (canceled)

36. A transdermal delivery device comprising:

a) a housing including

i) an external body shell comprising a fluid chamber assembly access cover movably engaged with the external body shell;

ii) an interior compartment including an open-ended delivery outlet and a vapor producing assembly compartment; and

iii) a cartridge retaining container comprising an external covering shell and an internal cartridge compartment configured to hold a compressed gas cartridge, wherein the cartridge retaining container is detachably engaged with the external body shell;

wherein the vapor producing assembly compartment is located in between the open-ended delivery outlet and the cartridge retaining container; and

b) a vapor producing assembly including

i) a fluid chamber assembly comprising a fluid container and a removable fluid container cap; and

ii) a permeation valve configured to reduce the pressure of a gas removed from the compressed gas cartridge and delivered to the fluid chamber assembly;

wherein the vapor producing assembly is substantially contained within the vapor producing assembly compartment.

37. The transdermal delivery device of claim 36, wherein the external covering shell defines the internal cartridge compartment.

38. The transdermal delivery device of claim 36, wherein the device further includes a control switch assembly.

39. The transdermal delivery device of claim 38, wherein the control switch assembly is a mechanical switch or an electronic switch.

40. The transdermal delivery device of claim 36, wherein the compressed gas cartridge is a 16 g compressed gas cartridge.

41. The transdermal delivery device of claim 36, wherein the compressed gas cartridge includes a compressed gas.

42. The transdermal delivery device of claim 41, wherein the compressed gas is carbon dioxide.

43. The transdermal delivery device of claim 36, wherein the permeation valve is configured to reduce gas pressure to below 40 psi.

44. The transdermal delivery device of claim 36, wherein the permeation valve comprises at least one permeable member selected from rubber, cork, textile, porous polymer, densely sintered metal or combinations thereof.

45. The transdermal delivery device of claim 36, wherein the fluid container includes water.

46. A transdermal delivery device comprising

a cylinder containing pressurized carbon dioxide;

a permeation valve configured to reduce the pressure of the pressurized carbon dioxide;

a chamber configured to supersaturate a liquid in the chamber with carbon dioxide thereby forming a therapeutic vapor; and

a treatment chamber configured to deliver the therapeutic vapor to an individual.

47. A method of producing a substance comprising a supersaturated amount of dissolved gas, the method comprising the steps of:

a) placing the substance in an air-tight container; and

b) exposing the substance to carbon dioxide, wherein upon exposure, the carbon dioxide dissolves into the substance in an amount greater than the substance could dissolve at 25°

C. and 1 atm.

48. The method of claim 47, wherein the substance is a liquid or a colloid.

49. The method of claim 48, wherein the colloid is a foam, a liquid, an aerosol, an emulsion, a gel, or a sol.

50. The method of claim 48, wherein the liquid is water at pH 4.

51. The method of claim 47, wherein dissolved carbon dioxide is produced at a concentration of at least 600 ppm.