5-CYANO-4- (PYRROLO [2,3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS
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Abstract
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
24 Citations
82 Claims
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1-74. -74. (canceled)
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75. A method of inhibiting PLK protein kinase activity in a patient or in a biological sample, comprising administering to said patient a compound represented by Structural Formula (I):
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76-80. -80. (canceled)
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81. A method of treating solid tumor, melanoma, myeloma, leukemia, lymphoma, neuroblastoma, or a cancer selected from colon, breast, gastric, ovarian, cervical, lung, central nervous system (CNS), renal, prostate, bladder, pancreatic, or urogenital cancer, lung cancer, gastrointestinal cancer, head and neck cancer, malignant mesothelioma, breast cancer, malignant melanoma, childhood cancer and bone or soft tissue sarcoma, in a patient wherein said method comprises administering to said patient a compound represented by Structural Formula (I):
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82-91. -91. (canceled)
Specification