PREVENTION OF ALCOHOL REACTION WITH DIETARY SUPPLEMENTS
First Claim
1. A composition for use by a subject to prevent or reduce the alcohol reaction, said composition comprising:
- a) an agent capable of increasing intracellular or intramitochondrial concentration of NAD in the subject; and
b) an agent capable of increasing glutathione concentration in the subject;
wherein said agents are present in the composition in an amount sufficient to prevent or reduce the alcohol reaction in the subject.
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Accused Products
Abstract
The present invention is directed to compositions for preventing or reducing the flush and other unpleasant symptoms that sometimes accompany the consumption of alcoholic beverages, and methods for use of said compositions. The compositions comprise an agent, or combinations of various agents, such as an agent capable of increasing intracellular or intramitochondrial concentration of NAD in the subject; an agent capable of increasing glutathione concentration in the subject; an anti-oxidant; alpha-lipoic acid or a precursor to alpha-lipoic acid; and/or an agent capable of increasing the level of Coenzyme A in the subject; where the agent or agents are present or administered in amounts effective to prevent or reduce the alcohol reaction in a subject who has consumed one or more alcoholic beverages.
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Citations
41 Claims
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1. A composition for use by a subject to prevent or reduce the alcohol reaction, said composition comprising:
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a) an agent capable of increasing intracellular or intramitochondrial concentration of NAD in the subject; and b) an agent capable of increasing glutathione concentration in the subject; wherein said agents are present in the composition in an amount sufficient to prevent or reduce the alcohol reaction in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of preventing or reducing at least one symptom of the alcohol reaction in a subject, comprising administering to the subject at least one agent selected from the group consisting of:
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an agent capable of increasing intracellular or intramitochondrial concentration of NAD in the subject, an agent capable of increasing glutathione concentration in the subject, and an agent capable of increasing cellular Coenzyme A concentrations in the subject; wherein the at least one agent is administered in an amount sufficient to prevent or reduce the alcohol reaction in the subject. - View Dependent Claims (15, 16, 17)
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18. A method of reducing blood levels of acetaldehyde resulting from dietary ethanol consumption by a human adult, comprising orally administering a daily dosage of
(i) between 300 mg and 1.5 g nicotinamide, (ii) between 10 mg and 500 mg pantothenic acid or a salt thereof, and (iii) between 100 mg and 600 mg N-acetylcysteine for a period of time selected from the group consisting of at least 3 days, 5 days, 10 days, 14 days, 21 days, and 28 days.
- 31. A composition comprising (i) between 300 mg and 1.5 g nicotinamide, (ii) between 10 mg and 500 mg pantothenic acid or a salt thereof, and (iii) between 100 mg and 600 mg N-acetylcysteine, and an excipient acceptable for daily oral administration.
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36. A composition for use by a subject to prevent or reduce the alcohol reaction, said composition comprising:
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a) an agent selected from the group consisting of nicotinamide, nicotinamide riboside, niacin, and oxaloacetate; and b) an agent selected from the group consisting of N-acetyl-cysteine, Vitamin C, alpha lipoic acid, L-cysteine, glutathione, glycine, L-glutamic acid, adenosylmethionine, and conjugated linoleic acid; wherein said agents are present in the composition in an amount sufficient to prevent or reduce the alcohol reaction in the subject. - View Dependent Claims (37, 38, 39, 40, 41)
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Specification