Method and System for Providing Calibration of an Analyte Sensor in an Analyte Monitoring System

• US 20140046157A1
• Filed: 10/17/2013
• Published: 02/13/2014
• Est. Priority Date: 08/09/2006
• Status: Abandoned Application

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary Alan, Doniger, Kenneth J., Budiman, Erwin Satrya, Zhang, Songbiao, Mazza, John Charles
• Application Number:
  US14/056,891
• Publication Number:
  US 20140046157A1
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

Method and apparatus for providing calibration of analyte sensor including applying a control signal, detecting a measured response to the control signal, determining a variance in the detected measured response, and estimating a sensor sensitivity based on the variance in the detected measured response is provided

Claims

1. (canceled)

2. A method for determining a property of a continuous analyte sensor, the method comprising:

applying a bias voltage to an analyte sensor;

applying a voltage step above the bias voltage to the analyte sensor;

measuring, using sensor electronics, a signal response of the voltage step;

determining, using the sensor electronics, a peak current of the signal response; and

determining, using the sensor electronics, a property of the sensor by correlating the peak current to a predetermined relationship.

3. The method of claim 2, wherein correlating the peak current to the predetermined relationship comprises calculating an impedance of the sensor based on the peak current and correlating the sensor impedance to the predetermined relationship.

4. The method of claim 2, wherein the property of the sensor is a sensitivity of the sensor or a temperature of the sensor.

5. The method of claim 2, wherein the peak current is a difference between a magnitude of the response prior to the voltage step and a magnitude of the largest measured response resulting from the voltage step.

6. The method of claim 2, wherein the predetermined relationship is an impedance-to-sensor sensitivity relationship, and wherein the property of the sensor is a sensitivity of the sensor.

7. The method of claim 2, further comprising compensating sensor data using the determined property of the sensor.

8. The method of claim 7, wherein the compensating comprises correlating a predetermined relationship of the peak current to sensor sensitivity or change in sensor sensitivity and modifying a value or values of the sensor data responsive to the correlated sensor sensitivity or change in sensor sensitivity.

9. The method of claim 8, wherein the predetermined relationship is a linear relationship over time of use of the analyte sensor.

10. The method of claim 8, wherein the predetermined relationship is a non-linear relationship over time of use of the analyte sensor.

11. The method claim 8, wherein the predetermined relationship is determined by prior testing of sensors similar to the analyte sensor.

12. A system for determining a property of a continuous analyte sensor, the system comprising a sensor electronics configured to be operably connected to a continuous analyte sensor, the sensor electronics configured to:

apply a bias voltage to an analyte sensor;

apply a voltage step above the bias voltage to the analyte sensor;

measure a signal response of the voltage step;

determine a peak current of the signal response; and

determine a property of the sensor by correlating the peak current to a predetermined relationship.

13. The system of claim 12, wherein correlating the peak current to the predetermined relationship comprises calculating an impedance of the sensor based on the peak current and correlating the sensor impedance to the predetermined relationship.

14. The system of claim 12, wherein the property of the sensor is a sensitivity of the sensor or a temperature of the sensor.

15. The system of claim 12, wherein the peak current is a difference between a magnitude of the response prior to the voltage step and a magnitude of the largest measured response resulting from the voltage step.

16. The system of claim 12, wherein the predetermined relationship is an impedance-to-sensor sensitivity relationship, and wherein the property of the sensor is a sensitivity of the sensor.

17. The system of claim 12, wherein the sensor electronics are further configured to compensate sensor data using the determined property of the sensor.

18. The system of claim 17, wherein the compensating comprises correlating a predetermined relationship of the peak current to sensor sensitivity or change in sensor sensitivity and modifying a value or values of the sensor data responsive to the correlated sensor sensitivity or change in sensor sensitivity.

19. The system of claim 18, wherein the predetermined relationship is a linear relationship over time of use of the analyte sensor.

20. The system of claim 18, wherein the predetermined relationship is a non-linear relationship over time of use of the analyte sensor.

21. The system of claim 18, wherein the predetermined relationship is determined by prior testing of sensors similar to the analyte sensor.

22. The system of claim 12, wherein the sensor electronics comprise a processor module, the processor module comprising instructions stored in computer memory, wherein the instructions, when executed by the processor module, cause the sensor electronics to apply the bias voltage to the analyte sensor, apply the voltage step above the bias voltage to the analyte sensor;

measure the signal response of the voltage step, determine the peak current of the signal response, and determine the property of the sensor by correlating the peak current to the predetermined relationship.