POLYMER MEMBRANES FOR CONTINUOUS ANALYTE SENSORS

• US 20140046158A1
• Filed: 10/18/2013
• Published: 02/13/2014
• Est. Priority Date: 03/28/2008
• Status: Active Grant

• Current Assignee: DexCom Incorporated
• Original Assignee: DexCom Incorporated
• Inventors: Boock, Robert J., Rixman, Monica A., Zhang, Huashi, Estes, Michael J., Lawrence, Kristina
• Granted Patent: US 8,954,128 B2
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1468 using chemical or electrochemical methods, e.g. by polarographic means A61B5/1486 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: B33Y 70/00 Materials specially adapted for additive manufacturing
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/40 Semi-permeable membranes or partitions

Abstract

Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.

Claims

1. A system for continuous in vivo measurement of a glucose concentration, the system comprising:

an implantable sensor configured to continuously measure a signal indicative of a glucose concentration in a host; and

a membrane located over the sensor, wherein the membrane comprises a first domain comprising an enzyme configured to react with glucose to produce a measured species configured to be oxidized at the sensor, wherein the membrane comprises a second domain comprising a blend comprising;

a polymer comprising a hydrophilic segment, and

a polyurethane comprising a plurality of repeating hard segments and repeating soft segments and a hydrophobic end group, wherein a soft segment of the plurality of repeating soft segments has a molecular weight from about 200 Daltons to about 50,000 Daltons, wherein a hard segment of the plurality of repeating hard segments has a molecular weight from about 160 Daltons to about 10,000 Daltons, wherein the blend of the polymer and the polyurethane comprises both hydrophilic and hydrophobic regions, whereby diffusion of glucose and oxygen through the second domain is controlled; and

sensor electronics operably connected to the sensor, wherein the sensor electronics are configured to measure a current flow produced by the sensor to generate sensor data indicative of glucose concentration.

2. The system of claim 1, wherein the hydrophilic regions collectively comprise 5% to 50% by weight of the second domain.

3. The system of claim 1, wherein the silicone end group is covalently bonded to the backbone.

4. The system of claim 1, wherein a thickness of the second domain is from about 1 micron to about 25 microns.

5. The system of claim 1, wherein the sensor comprises an electrode.

6. The system of claim 1, wherein the polyurethane comprises at least about 10% silicone by weight percent.

7. The system of claim 1, wherein the polyurethane comprises from about 19% to about 40% silicone by weight percent.