NON-CONTRAST MRI WITH DIFFERENTIATION OF ISCHEMIC, INFARCT AND NORMAL TISSUE
First Claim
1. A magnetic resonance imaging (MRI) system comprising:
- an MRI gantry having static and gradient magnet assemblies and at least one radio frequency (RF) coil defining an image volume into which a patient region of interest (ROI) can be disposed;
MRI control circuits connected to control components within said MRI gantry and configured to effect MRI data acquisition sequences of RF and gradient magnetic pulses which elicit MRI signals from patient tissue when an ROI is disposed therein, to acquire and process said elicited MRI signals into MR image data in conjunction (a) with use of an initial spatially-selective nuclear magnetic resonance (NMR) RF tag pulse (tag-on) in a data acquisition subsequence and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in a data acquisition subsequence;
said MRI control circuits being configured to(a) acquire multi-dimensional MR k-space data for a patient ROI using said tag-on and tag-off data acquisition subsequences for each of plural time to inversion (TI) intervals without using an injected contrast agent;
(b) reconstruct said acquired k-space data into spatial domain tag-on and tag-off MR image data;
(c) subtract said acquired tag-off and tag-on MR image data for each of plural TI intervals to produce difference image data as a function of time representing blood perfusion in said ROI having a corresponding flow time and/or relative peak blood flow magnitude, or lack thereof, for said ROI which differentiates between normal, ischemic and infarct tissues; and
(d) store and/or display perfusion data of the ROI having values which are different for normal, ischemic and infarct tissues.
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Accused Products
Abstract
Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.
13 Citations
20 Claims
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1. A magnetic resonance imaging (MRI) system comprising:
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an MRI gantry having static and gradient magnet assemblies and at least one radio frequency (RF) coil defining an image volume into which a patient region of interest (ROI) can be disposed; MRI control circuits connected to control components within said MRI gantry and configured to effect MRI data acquisition sequences of RF and gradient magnetic pulses which elicit MRI signals from patient tissue when an ROI is disposed therein, to acquire and process said elicited MRI signals into MR image data in conjunction (a) with use of an initial spatially-selective nuclear magnetic resonance (NMR) RF tag pulse (tag-on) in a data acquisition subsequence and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in a data acquisition subsequence; said MRI control circuits being configured to (a) acquire multi-dimensional MR k-space data for a patient ROI using said tag-on and tag-off data acquisition subsequences for each of plural time to inversion (TI) intervals without using an injected contrast agent; (b) reconstruct said acquired k-space data into spatial domain tag-on and tag-off MR image data; (c) subtract said acquired tag-off and tag-on MR image data for each of plural TI intervals to produce difference image data as a function of time representing blood perfusion in said ROI having a corresponding flow time and/or relative peak blood flow magnitude, or lack thereof, for said ROI which differentiates between normal, ischemic and infarct tissues; and (d) store and/or display perfusion data of the ROI having values which are different for normal, ischemic and infarct tissues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A magnetic resonance imaging (MRI) method comprising:
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(a) acquiring multi-dimensional MR k-space data for a patient ROI using RF tag-on and RF tag-off data acquisition subsequences for each of plural time to inversion (TI) intervals without using an injected contrast agent; (b) reconstructing said acquired k-space data into spatial domain tag-on and tag-off MR image data; (c) subtracting said acquired tag-off and tag-on MR image data for each of plural TI intervals to produce difference image data as a function of time representing peak blood flow time and/or relative peak blood flow magnitude data, or lack thereof, for said ROI which differentiates between normal, ischemic and infarct myocardial tissues; and (d) storing and/or displaying image data of the ROI having values which are different for normal, ischemic and infarct tissues. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification