System and Apparatus for Automated Quantitative Assessment, Optimization and Logging of the Effects of a Therapy
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Abstract
A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject'"'"'s brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.
17 Citations
21 Claims
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1-14. -14. (canceled)
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15. A method for optimizing the effect of a therapy, comprising:
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determining a wave rhythmicity of brain activity of a subject, and applying a therapy to a target tissue of said subject at a first time, wherein said target tissue and said first time are based upon said wave rhythmicity.
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16. A method for optimizing the effect of a therapy, comprising:
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estimating the level of synchrony within one brain epileptogenic region, and determining if said level of synchrony is above or below a value associated with a high probability of blockage of an epileptic event when said therapy is applied. - View Dependent Claims (17)
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18. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs a method of optimizing the effects of a therapy, the method comprising:
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(a) determining the spatio-temporal behavior of one or more of a patient'"'"'s seizures and said patient'"'"'s response to a therapy in one or more dimensions, at one or more sites, at one or more points in time, at one or more time-scales, and at one or more frequencies; (b) building a probability density function based on said spatio-temporal behavior; (c) creating a library of seizure features; (d) cataloging the one or more seizures according to a degree of similarity to at least one of the seizure or therapy response features; (e) classifying said one or more seizures as known or unknown ; (f) creating a library of treatment and parameter modalities; (g) classifying said treatment modalities as beneficial or detrimental; (h) saving at least one feature of said one or more seizures into a library of unmatched events if it does not match a known seizure type; (i) saving at least one therapy response to a beneficial treatment library if it is beneficial or to a detrimental treatment library if it is detrimental; (j) optimizing the therapy parameters; and (k) saving the optimized parameters. - View Dependent Claims (19, 20, 21)
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Specification