Binding Agents That Modulate the Hippo Pathway and Uses Thereof
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to agents that modulate the Hippo pathway and Hippo pathway signaling, such as antibodies and soluble receptors, as well as to methods of using the agents for the treatment of diseases such as cancer.
-
Citations
101 Claims
-
1-80. -80. (canceled)
-
81. An agent that specifically binds the extracellular domain of one or more cell adhesion molecules of the immunoglobulin superfamily (IgCAM), wherein the IgCAM is selected from the group consisting of:
- AMICA, CAR, CLMP, ESAM, GPA33, VSIG1, VSIG2, VSIG3, VSIG4, VSIG8, JAM1, JAM2, JAM3, CADM1, CADM2, CADM3, CADM4, CRTAM, TMIGD1, PVR, PVRL1, PVRL2, PVRL3, PVRL4, PVRIG, CD200, CD200R1, CD200R1L, CD226, CD96, TIGIT, and TMEM25.
- View Dependent Claims (82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101)
Specification