DEVICES AND METHODS FOR BIOLOGICAL SAMPLE-TO-ANSWER AND ANALYSIS
First Claim
Patent Images
1. A cartridge comprising:
- a first part, wherein the first part is transparent to electromagnetic waves of a desired wavelength range and has an inner surface defining a first surface of at least one reaction chamber;
a central part, attached to the first part, wherein the central part has an inner surface defining sidewalls of the at least one reaction chamber; and
a metal back plate, attached to the central part, wherein the metal back plate has an inner surface defining a second surface of the at least one reaction chamber,wherein the first part comprises;
a transparent top layer configured to act as a waveguide and focus or direct electromagnetic waves onto the at least one reaction chamber;
at least one prism, attached to a side of the transparent top layer and configured to focus or direct electromagnetic waves onto the transparent top layer;
at least one handle;
at least one opening in the transparent top layer; and
at least one fluidics channel connecting the at least one opening to the at least one reaction chamber.
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Abstract
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. Different functional elements, such as grinders or mixers, may be attached to the containers. The device may have a reaction cartridge with a reaction chamber to perform techniques such as polymerase chain reaction.
17 Citations
36 Claims
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1. A cartridge comprising:
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a first part, wherein the first part is transparent to electromagnetic waves of a desired wavelength range and has an inner surface defining a first surface of at least one reaction chamber; a central part, attached to the first part, wherein the central part has an inner surface defining sidewalls of the at least one reaction chamber; and a metal back plate, attached to the central part, wherein the metal back plate has an inner surface defining a second surface of the at least one reaction chamber, wherein the first part comprises; a transparent top layer configured to act as a waveguide and focus or direct electromagnetic waves onto the at least one reaction chamber; at least one prism, attached to a side of the transparent top layer and configured to focus or direct electromagnetic waves onto the transparent top layer; at least one handle; at least one opening in the transparent top layer; and at least one fluidics channel connecting the at least one opening to the at least one reaction chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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Specification