System and Mandrel for Creating Graft Devices

• US 20140058194A1
• Filed: 02/08/2012
• Published: 02/27/2014
• Est. Priority Date: 02/09/2011
• Status: Active Grant

• Current Assignee: Xeltis AG (Technische Universiteit Eindhoven)
• Original Assignee: Neograft Technologies, Inc.
• Inventors: Soletti, Lorenzo, El-Kurdi, Mohammed S., McGrath, Jon, Flaherty, J. Christopher, Vu, Liem, Brightbill, Jerry, Evans, Stephen, Robinson, Timothy, Ting, Joseph, Rezac, David
• Granted Patent: US 9,867,690 B2
• Time in Patent Office: Days
• US Class Current: 600/36
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00969 used for transplantation
• CPC Class Codes: A61F 2/062 Apparatus for the production of blood vessels made from natural tissue or with layers of living cells prostheses made from natural tissue or living cells A61L27/507
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: B05B 13/0436 Installations or apparatus for applying liquid or other fluent material to elongated bodies, e.g. light poles, pipes B05B13/0442, B05B13/0463 take precedence
• CPC Class Codes: B05B 13/0627 Arrangements of nozzles or spray heads specially adapted for treating the inside of hollow bodies B05B13/0645 takes precedence

Abstract

A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided.

Claims

1-290. -290. (canceled)

291. A system for applying a fiber matrix on a tubular member, the system comprising:

a fiber matrix delivery assembly;

a tubular member; and

a mandrel comprising a mandrel first end and a mandrel second end, wherein the mandrel is constructed and arranged to be atraumatically inserted into the tubular member, radially expanded within the tubular member, and attached to the fiber matrix assembly.

292. The system of claim 291, wherein the mandrel further comprises a lumen.

293. The system of claim 291, wherein the mandrel further comprises:

a porous portion, and

wherein the system is constructed and arranged to deliver fluid from the porous portion to the tubular member.

294. The system of claim 291, wherein the mandrel comprises:

a middle portion, and at least one of the mandrel first end or the mandrel second end comprises a smaller diameter than a diameter of the middle portion.

295. The system of claim 291, wherein the mandrel comprises:

a shaft, and

a balloon surrounding the shaft.

296. The system of claim 291, wherein the mandrel comprises a braided construction.

297. The system of claim 291, wherein the mandrel comprises a helical construction.

298. The system of claim 291, wherein the mandrel comprises a compressible tube constructed and arranged to radially expand when compressed.

299. The system of claim 291, wherein the mandrel is constructed and arranged to radially expand when exposed to a fluid.

300. The system of claim 291, wherein the mandrel comprises:

a compressible tube constructed and arranged to radially expand when compressed.

301. The system of claim 291, wherein the mandrel further comprises:

a guidewire attached to the mandrel first end.

302. The system of claim 301, wherein the guidewire is constructed and arranged to be removed from the mandrel first end.

303. The system of claim 291, wherein the system further comprises:

a fluid delivery device operably attachable to at least one of the mandrel first end or the mandrel second end.

304. The system of claim 291, further comprising:

a rotational drive constructed and arranged to rotate the mandrel.

305. The system of claim 291, wherein the fiber matrix delivery assembly comprises an electrospinning unit.

306. The system of claim 291, wherein the tubular member comprises:

living tissue selected from the group consisting of;

vein, saphenous vein, artery, lymphatic duct, vas deferens, tear duct, intestine, esophagus, ureter, urethra, trachea, bronchi, duct tissue, Eustachian tube, fallopian tube, and combinations thereof.

307. The system of claim 291, wherein the tubular member comprises a saphenous vein.

308. The system of claim 291, wherein the tubular member comprises:

an artificial conduit selected from the group consisting of;

polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), polyvinylidene fluoride/hexafluoropropylene (PVDF-HFP), polyester, silicone, polyethylene, polypropylene, polyester-based polymer, polyether-based polymer, thermoplastic rubber, and combinations thereof.