EXTERNAL PREPARATION COMPOSITION COMPRISING FATTY ACID-BASED IONIC LIQUID AS ACTIVE INGREDIENT
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Abstract
Disclosed is an external preparation composition having good transdermal absorbability. An external preparation composition having excellent transdermal absorbability can be produced by dissolving a medicinal substance or a salt thereof in a fatty acid-based ionic liquid to form a composite ionic composition of the medicinal substance. The external preparation composition can be used as a liquid preparation, an ointment, a cream, a plaster or the like, and enables to provide a preparation having excellent transdermal absorbability.
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Citations
41 Claims
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1-25. -25. (canceled)
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26. A nonaqueous external preparation composition comprising a drug or a salt thereof dissolved in a fatty acid-based ionic liquid having 5 to 20 carbon atoms,
wherein the drug is a basic drug; the fatty acid-based ionic liquid is an equimolar salt(s) of one or more fatty acid(s) and one or more organic amine compound(s), and is obtained from a fatty acid having 5 to 20 carbon atoms and an organic amine compound having 4 to 12 carbon atoms - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
- 38. A transdermal absorption accelerator for a basic drug or a salt thereof, comprising as an active ingredient, a fatty acid-based ionic liquid which is an equimolar salt(s) of one or more fatty acid(s) having 5 to 20 carbon atoms and one or more organic amine compound(s) having 4 to 12 carbon atoms.
Specification