SYSTEM FOR IN-VIVO MEASUREMENT OF AN ANALYTE CONCENTRATION

• US 20140066730A1
• Filed: 11/11/2013
• Published: 03/06/2014
• Est. Priority Date: 03/20/2007
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Roesicke, Bernd, Obermaier, Karin, Lindegger, Stefan, Menke, Andreas, Scherer, Joerg, Schwind, Karin, Gaa, Otto, Bainczyk, Gregor, Marquant, Michael, Niederhauser, Sandro, Schoemaker, Michael, Mueri, Martin
• Granted Patent: US 9,636,049 B2
• Time in Patent Office: Days
• US Class Current: 600/309
• CPC Class Codes: A61B 2560/0209 adapted for power saving
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2560/0481 in implanted apparatus
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 90/98 using electromagnetic means, e.g. transponders

Abstract

The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.

Claims

1. A method of compressing data from in-vivo measurement of an analyte concentration in a human, comprising:

forming pairs of measurement signals from raw data values of in-vivo measurements of an analyte concentration generated for a time interval;

determining a slope of a line connecting each pair of measurement signals;

calculating a median value of each slope of the line connecting each pair of measurement signals; and

calculating a compressed data value for the time interval from the median value of each slope of the line connecting each pair of measurement signals and a compressed data value of a preceding time interval.

2. The method as in claim 1, further comprising,

disregarding raw data that are a substantial deviation from other raw data values.

3. The method as in claim 1, further comprising,

determining raw data values consecutively over constant time intervals using time marks including a date and a time.

4. The method as in claim 1, wherein,

calculating a median value includes disregarding raw data values that deviate by more than a threshold value from a mean value of other raw data values.

5. The method as in claim 1, further comprising,

sending the calculated compressed data value from a base station to a display device.

6. A method of compressing data from in-vivo measurement of an analyte concentration in a human, comprising:

providing a plurality of consecutive raw data values of in-vivo measurements of an analyte concentration for a first time interval;

calculating a compressed data value for the first time interval by calculating a median value of the raw data values;

providing a plurality of raw data values for a later time interval;

calculating a compressed data value for the later time interval from the compressed data value of the first time interval and a slope value determined for the later time interval.

7. The method as in claim 6, wherein the later time interval overlaps the first time interval.

8. The method as in claim 6, wherein,

calculating a median value of the raw data values includes disregarding raw data values that deviate by more than a threshold value from a mean value of other raw data values.

9. The method as in claim 6, further comprising,

sending the calculated compressed data value for the later time interval from a base station to a display device.

10. A method of compressing data from in-vivo measurement of an analyte concentration in a human, comprising:

forming pairs of raw data values of in-vivo measurements of an analyte concentration, which were generated for a first time interval;

determining, for each pair of raw data values, a slope value of a line connecting the pair of raw data values;

calculating a median value of the slope values of lines connecting the pairs of raw data values;

calculating a compressed data value for the first time interval from the median slope value and a compressed data value of a preceding time interval;

forming pairs of compressed data values generated for a second time interval containing a plurality of first time intervals;

determining, for each pair of compressed data values, a slope value of a line connecting the pair of compressed data values;

calculating a median value of the slope values of lines connecting pairs of compressed data values; and

calculating a condensed data value for the second time interval from the median value of the slope values of the lines connecting pairs of compressed data values and a condensed data value of a preceding second time interval.

11. The method of claim 10, wherein the second time interval overlaps the preceding second time interval.

12. The method as in claim 10, wherein,

calculating a median value of the slope values of lines connecting the pairs of raw data values includes disregarding raw data values that deviate by more than a threshold value from a mean value of other raw data values.

13. The method as in claim 10, further comprising,

sending the condensed data value for the second time interval from a base station to a display device.