CHARACTERIZATION OF TISSUE BY ULTRASOUND ECHOGRAPHY

• US 20140066764A1
• Filed: 09/04/2013
• Published: 03/06/2014
• Est. Priority Date: 09/05/2012
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Subramaniam, Raj, Onishi, Steven T.
• Application Number:
  US14/018,386
• Publication Number:
  US 20140066764A1
• Time in Patent Office: Days
• US Class Current: 600/438
• CPC Class Codes: A61B 18/1482 having a long rigid shaft for accessing the inner body transcutaneously in minimal invasive surgery, e.g. laparoscopy
• CPC Class Codes: A61B 2017/0011 piezoelectric
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 8/02 Measuring pulse or heart rate
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61B 8/4488 the transducer being a phased array
• CPC Class Codes: A61B 8/486 involving arbitrary m-mode

Abstract

Various embodiments concern sensing a first signal indicative of a plurality of different phases of a cardiac cycle with a sensor and sensing a second signal with an ultrasound sensor within the heart over different phases, the second signal indicative of the density of a section of cardiac tissue. Each phase can be associated with an indication of the density of the section of cardiac tissue during the phase based on the second signal. It can be determined whether the section of cardiac tissue compressed during the cardiac cycle based on a change in the indication of density of the cardiac tissue over the plurality of different phases. The efficacy of ablation therapy can be evaluated based on the compressibility of the section of cardiac tissue.

Claims

1. A system comprising:

at least one catheter having a distal end configured to be introduced into the heart;

at least one ultrasound sensor on the distal end of the at least one catheter, the at least one ultrasound sensor configured to output a first signal indicative of the intensity of ultrasound energy received by the ultrasound sensor from a section of cardiac tissue, the intensity of the ultrasound energy indicative of the density of the section of cardiac tissue;

a sensor configured to output a second signal indicative of a plurality of different phases of at least one cardiac cycle; and

control circuitry configured to associate each phase of the plurality of different phases of the at least one cardiac cycle with the intensity level of ultrasound energy received by the ultrasound sensor from the section of cardiac tissue during the phase, determine whether the section of cardiac tissue compressed during the at least one cardiac cycle based on a difference between the intensity levels of ultrasound energy associated with different phases of the at least one cardiac cycle, and generate an output based on the determination of whether the section of cardiac tissue compressed.

2. The system of claim 1, wherein the control circuitry is configured to determine that the section of cardiac tissue compressed if the intensity level of ultrasound energy associated with a systolic phase is greater relative to the intensity level of ultrasound energy associated with a diastolic phase and that the section of cardiac tissue did not compress if the intensity level of ultrasound energy associated with the systolic phase is similar to the intensity level of ultrasound energy associated with the diastolic phase.

3. The system of claim 1, wherein the difference between the intensity levels of ultrasound energy associated with different phases of the at least one cardiac cycle is indicative of a change in density of the section of cardiac tissue between the different phases of the at least one cardiac cycle.

4. The system of claim 1, further comprising a display, wherein the control circuitry is configured to generate an indication on the display of the state of the section of cardiac tissue based on the determination of whether the section of cardiac tissue compressed.

5. The system of claim 1, further comprising a display, wherein the control circuitry is configured to generate a cardiac map on the display and highlight the section of cardiac tissue on the cardiac map based on the control circuitry determining that the section did not compress.

6. The system of claim 1, further comprising an ablation element configured to output a cardiac ablation therapy, wherein the control circuitry is configured to determine whether the section of cardiac tissue was ablated by the cardiac ablation therapy based on the determination of whether the section of cardiac tissue compressed.

7. The system of claim 1, further comprising an ablation element configured to output a cardiac ablation therapy, wherein the control circuitry is configured to repeatedly or continuously deliver the cardiac ablation therapy with the ablation element to the section of cardiac tissue until the control circuitry determines that the section of cardiac tissue no longer compresses.

8. The system of claim 1, wherein:

the first signal is indicative of the level of ultrasound energy received by the ultrasound sensor from an additional section of cardiac tissue that is adjacent to the section of cardiac tissue; and

the control circuitry is configured to associate each phase of the plurality of different phases of the at least one cardiac cycle with the intensity level of ultrasound energy received by the at least one ultrasound sensor from the additional section of cardiac tissue during the phase and determine whether the section of cardiac tissue compressed during the at least one cardiac cycle relative to the additional section of cardiac tissue based on the intensity levels of ultrasound energy associated with the different phases of each of the section and the additional section of cardiac tissue.

9. The system of claim 1, wherein the control circuitry is configured to process the first signal in accordance with A-mode ultrasound operation.

10. The system of claim 1, wherein the control circuitry is configured to selectively sample the first signal only during respective portions of the plurality of different phases based on the second signal to associate each phase of the plurality of different phases with the intensity level of ultrasound energy received by the at least one ultrasound sensor during the respective portion of the phase.

11. The system of claim 1, wherein the control circuitry is configured to reduce or eliminate changes in the intensity level of the ultrasound energy of the first signal due to wall motion of the section of cardiac tissue.

12. A method of assessing cardiac ablation, the method comprising:

delivering an ablation therapy to a section of cardiac tissue, the ablation therapy delivered by a catheter to the section of cardiac tissue;

sensing a first signal indicative of a plurality of different phases of at least one cardiac cycle with a sensor;

sensing a second signal with one or more ultrasound sensors within the heart over the plurality of different phases of the at least one cardiac cycle, the second signal indicative of the density of a section of cardiac tissue;

associating each phase of the plurality of different phases of the at least one cardiac cycle with an indication of the density of the section of cardiac tissue during the phase based on the second signal;

determining whether the section of cardiac tissue compressed during the at least one cardiac cycle based on a change in the indication of density of the section of cardiac tissue over the plurality of different phases of the at least one cardiac cycle; and

determining whether the section of cardiac tissue was ablated by the delivery of the ablation therapy based on whether the section of cardiac tissue compressed during the at least one cardiac cycle.

13. The method of claim 12, wherein determining whether the section of cardiac tissue compressed comprises:

determining that the section compressed if the density of the section associated with the systolic phase is indicated to be greater than the density of the section associated with the diastolic phase; and

determining that the section did not compress if the density of the section associated with the systolic phase is indicated to be similar to the density of the section associated with the diastolic phase.

14. The method of claim 12, further comprising redelivering the ablation therapy to the section of cardiac tissue if it is determined that the section of cardiac tissue was not ablated by the delivery of the ablation therapy.

15. The method of claim 12, wherein the plurality of different phases of the at least one cardiac cycle comprises at least a diastole phase and a systole phase.

16. The method of claim 12, wherein sensing the second signal comprises selectively sensing the second signal only during respective portions of the plurality of different phases based on the first signal to associate each phase of the plurality of different phases with the indication of the density of the section of tissue during the phase.

17. The method of claim 12, wherein the density of the section of cardiac tissue is indicated by the intensity level of ultrasound energy received by the second sensor as reflected from the section of cardiac tissue.

18. A system comprising:

at least one catheter having a distal end configured to be introduced into the heart;

at least one ultrasound sensor on the distal end of the at least one catheter, the at least one ultrasound sensor configured to output a first signal indicative of the intensity level of ultrasound energy received by the at least one ultrasound sensor from a section of cardiac tissue, the intensity level of ultrasound energy received by the at least one ultrasound sensor indicative of the density of the section of cardiac tissue;

a sensor configured to output a second signal indicative of a plurality of different phases of at least one cardiac cycle;

a display; and

control circuitry configured to associate each phase of the plurality of different phases of the at least one cardiac cycle with the intensity level of ultrasound energy received by the at least one ultrasound sensor from the section of cardiac tissue within the phase and generate an output on the display representing the intensity levels of ultrasound energy as associated with the different phases of the plurality of different phases of the at least one cardiac cycle, the output on the display indicative of whether the section of cardiac tissue compressed during the at least one cardiac cycle.

19. The system of claim 18, wherein the output on the display comprises overlaid signal traces, each signal trace of the overlaid signal traces representing the intensity level of ultrasound energy as associated with a respective phase of the plurality of different phases of the at least one cardiac cycle.

20. The system of claim 18, wherein the control circuitry is further configured to label at least one phase of the plurality of different phases as a systolic phase and label at least one other phase of the plurality of different phases as a diastolic phase in the output generated on the display based on the second signal.