BENEFICIAL AGENT DISPENSER

• US 20140066846A1
• Filed: 11/08/2011
• Published: 03/06/2014
• Est. Priority Date: 11/08/2010
• Status: Abandoned Application

• Current Assignee: Aktivpak, Inc.
• Original Assignee: Aktivpak, Inc.
• Inventors: Genosar, Amir
• Application Number:
  US13/884,246
• Publication Number:
  US 20140066846A1
• Time in Patent Office: Days
• US Class Current: 604/89
• CPC Class Codes: A61J 1/067 Flexible ampoules, the contents of which are expelled by squeezing
• CPC Class Codes: A61J 1/2093 Containers having several compartments for products to be mixed
• CPC Class Codes: A61J 1/2096 Combination of a vial and a syringe for transferring or mixing their contents
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2455 with sealing means to be broken or opened
• CPC Class Codes: A61M 5/282 by compression of deformable ampoule or carpule wall
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/285 with sealing means to be broken or opened
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/50 having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile retractable needles or needle protectors with means for preventing re-use A61M5/321

Abstract

A dispensing device for use with a beneficial agent has a dispensing package, a dispenser disposed on an end portion of the dispensing package, and an actuator movably disposed along at least a portion of the package between a pre-dispensing state and a dispensing state. One arrangement also provides a beneficial agent dispenser having a dispensing port, an elongate portion and a plunger that is movably disposed relative to a tubular wall of the elongate portion during a dispensing stroke to partially penetrate a separable barrier and expel the beneficial agent through the dispensing port.

Claims

1. A dispensing device for use with a beneficial agent, comprising:

a dispensing package, comprising;

an elongate, at least partially flexible member comprising a sealed tubular compartment and at least one separable barrier enclosing one end of said tubular compartment; and

one of a beneficial agent or a constituent of a beneficial agent contained in said tubular compartment;

a dispenser disposed on a dispensing end portion of said package; and

an actuator movably disposed along at least a portion of said package between a pre-dispensing state and a dispensing state.

2. A dispensing device according to claim 1 wherein said separable barrier is formed along said tubular wall by pinching said one end of said tubular compartment and thereafter sealing across said one end.

3. A dispensing device according to claim 1 wherein said separable barrier defines a distal end of said tubular compartment.

4. A dispensing device according to claim 1 wherein said separable barrier defines a proximal end of said first compartment.

5. A dispensing device according to claim 1 wherein said first compartment stores a first constituent of the beneficial agent, and further comprising at least a second compartment storing a second constituent of the beneficial agent, and wherein said separable barrier is located between said first and second compartments.

6. A dispensing device according to claim 1 wherein said separable barrier is located between said first compartment and said dispensing end portion.

7. A dispensing device according to claim 1 wherein said tubular wall comprises a multi-layer material.

8. A dispensing device according to claim 1 where said tubular wall is an extrusion.

9. A dispensing device according to claim 8 wherein said tubular wall is made from an extruded sheet rolled and seamed to form a tube.

10. A dispensing device according to claim 1 wherein said dispensing end portion includes a dispensing port and said actuator comprises a plunger and a piston joined to said plunger, said tubular wall extending to aseptically enclose at least one of said dispensing port, said plunger, and said piston.

11. A dispensing device according to claim 5 further comprising a peelable foil, substantially protecting at least one of said first and second compartments from an ambient environment.

12. A dispensing device according to claim 11 wherein said peelable foil is attached to at least one of said first and second separable barriers.

13. A dispensing device according to claim 12 wherein said peelable foil extends to provide an aseptic enclosure to one of the group of a dispensing port, a plunger, and a piston.

14. A dispensing device according to claim 1 wherein said dispenser is selected from a group consisting of a needle, a micro-needle, an intra-dermal needle, a subcutaneous needle, an intramuscular needle, an IV catheter, a jet injection nozzle, a catheter, a tube, a hose, a topical applicator, a nasal applicator, an auricular dispenser, an ocular dispenser, a dropper, an adapter, or a connector to one of the above.

15. A dispensing device according to claim 1 further comprising a housing surrounding at least a portion of said tubular wall.

16. A dispensing device according to claim 15 wherein said housing restricts movement of said tubular wall toward a distal end of said housing.

17. A dispensing device according to claim 16 wherein said tubular wall is moveable toward a proximal end of said housing to draw said dispenser at least partially into said housing.

18. A dispensing device according to claim 1 wherein said actuator comprises a roller operative to collapse said tubular wall resulting in expulsion of said beneficial agent.

19. A dispensing device according to claim 1 wherein said actuator comprises at least one compression panel operative to collapse said tubular wall resulting in expulsion of said beneficial agent.

20. A dispensing device according to claim 1 wherein said actuator comprises a pressure chamber adapted to receive at least a portion of said tubular wall such that elevated pressure in said pressure chamber results in expulsion of said beneficial agent.

21. A dispensing device according to claim 1 wherein said actuator comprises a plunger.

22. A dispensing device according to claim 1 wherein said dispenser includes a dispensing port, and wherein at least a portion of said dispenser is moveable toward the proximal end of said tubular wall to conceal at least a portion of said dispensing port.

23. A dispensing device according to claim 5 wherein movement of said actuator causes said first and second constituents to mix and thereafter be expelled through said dispenser.

24. A beneficial agent dispensing device, comprising:

an elongate portion, comprising;

a first compartment for storing a first constituent of the beneficial agent, said first compartment comprising a tubular wall;

at least a second compartment for storing at least a second constituent of the beneficial agent; and

at least a first separable barrier located between said first and second compartments;

a dispenser; and

a plunger comprising a plunger portion moveably disposed in said tubular wall between a pre-dispensing position wherein said plunger portion is outside said first compartment, and a dispensing position wherein said plunger portion is at least partially disposed within said second compartment.

25. A dispensing device according to claim 24 further comprising a piston attached to said plunger.

26. A dispensing device according to claim 24 further comprising a second separable barrier located between said second compartment and said dispenser.

27. A dispensing device according to claim 24 further comprising a second separable barrier located between said first compartment and said plunger.

28. A dispensing device according to claim 24 wherein said dispenser is selected from a group consisting of a needle, a micro-needle, an intradermal needle, a subcutaneous needle, an intramuscular needle, an IV catheter, a jet injection nozzle, a catheter, a tube, a hose, a topical applicator, a nasal applicator, an auricular dispenser, an ocular dispenser, a dropper, an adapter, or a connector to any of the above.

29. A dispensing device according to claim 24 wherein said tubular wall comprises molded plastic.

30. A dispensing device according to claim 24 wherein at least one of said first and second compartments comprises a flexible tube.

31. A dispensing device according to claim 24 wherein said separable barrier comprises a rupturable foil.

32. A dispensing device according to claim 27 wherein at least one said first and second separable barriers comprises a tubular portion that has been crimped and sealed there across.

33. A dispensing device according to claim 24 further comprising a second plunger portion operative to couple with said first plunger portion as said second plunger portion moves toward said dispenser.

34. A beneficial agent dispenser, comprising:

a dispensing port;

an elongate portion, comprising;

a first compartment for storing a first constituent of the beneficial agent, said first compartment comprising a tubular wall; and

at least a first separable barrier located between said first compartment and said dispensing port; and

a plunger comprising a first plunger portion moveably disposed relative to said tubular wall during a dispensing stroke to partially penetrate said first separable barrier and expel the beneficial agent through said dispensing port.

35. A dispenser according to claim 34 further comprising a piston attached to said plunger.

36. A dispenser according to claim 34 further comprising a second compartment disposed between said first compartment and said dispensing port, said at least a first separable barrier located between said first and second compartments.

37. A dispenser according to claim 34 further comprising a second separable barrier located between said first compartment and said plunger portion.

38. A dispenser according to claim 34 wherein said dispensing port is part of a dispensing device that is selected from a group consisting of a needle, a micro-needle, an intradermal needle, a subcutaneous needle, an intramuscular needle, an IV catheter, a jet injection nozzle, a catheter, a tube, a hose, an adapter, or a connector to any of the above.

39. A dispenser according to claim 34 wherein said tubular first compartment wall comprises molded plastic.

40. A dispenser according to claim 36 wherein said second compartment comprises a flexible tube.

41. A dispenser according to claim 36 where said first and second compartments comprises first and second flexible tubes, respectively.

42. A dispenser according to claim 34 wherein said at least one separable barrier comprises a rupturable foil.

43. A dispenser according to claim 37 wherein at least one of the said first and second separable barriers comprises a flexible tube section pinched and welded there across to form seal.

44. A dispenser according to claim 34 wherein first plunger portion is moveably disposed in said first tubular compartment, and further comprising at least a second plunger portion adapted to couple with said first plunger portion as it penetrates said first separable barrier.

45. A beneficial agent dispensing device, comprising:

a dispensing package comprising at least a first compartment constructed at least partially from a flexible tubular wall, and one of a beneficial agent or a constituent of a beneficial agent contained in said first compartment;

a dispenser disposed on a dispensing end portion of said package; and

an actuator movably disposed along at least a portion of said package between a pre-dispensing state and a dispensing state to expel contents of said at least a first compartment through said dispensing end portion.