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INSTRUMENT FOR MEASURING CARBON MONOXIDE POISONING OF HUMANS USING IN VIVO NIRS TECHNOLOGY

  • US 20140073891A1
  • Filed: 11/14/2013
  • Published: 03/13/2014
  • Est. Priority Date: 04/25/2007
  • Status: Abandoned Application
First Claim
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1. A method for non-invasively determining the relative amounts of a plurality of chromophores in the blood of a human or animal subject, the method comprising the steps of:

  • imparting non-continuously a wavelength range of light comprising visible and near-infrared components extending down to at least about 450 nm to a light delivery fiberoptic;

    passing the wavelength range of light through a selected tissue sample of the nasal septum of the human or animal subject and receiving a spectral absorption portion of the wavelength range of light in a light collecting fiberoptic;

    providing a spectrometer for receiving the spectral absorption portion of the wavelength range of light from the light collecting fiberoptic;

    acquiring a first spectrum of the spectral absorption portion of the wavelength range of light;

    acquiring a second spectrum of ambient light at a first predetermined time interval from the acquisition of the first spectrum;

    acquiring a third reference spectrum of light from the wavelength range of light at a second predetermined time interval from the acquisition of the second spectrum; and

    acquiring a fourth spectrum of ambient light at a third predetermined time interval from the acquisition of the reference spectrum;

    subtracting an average of the second and fourth ambient light spectrum from each of the first and third spectrum to determine a total absorption spectra of the selected tissue sample for a plurality of wavelengths selected from the wavelength range of light; and

    recording light intensity at each and substantially every wavelength in the spectral range of the spectrometer for each of the plurality of wavelengths;

    performing decomposition of the total absorption spectra by comparing light intensity at a first wavelength to light intensity at adjacent wavelengths to determine the concentration of the plurality of chromophores;

    assembling a catalog of chromophore spectra from the recorded light intensity at each wavelength in the spectral range of the spectrometer for each of the plurality of chromophores separately by measuring each wavelength individually at the determined concentration and recorded wavelength to evaluate the spectral shape to determine the spectral signature for the chromophore;

    deconvolving the total absorption spectra to determine a relative contribution of each of the plurality of chromophores in the blood of a human or animal subject; and

    identifying at least one chromophore and its concentration in the blood of the human or animal subject from the catalog of chromophore spectra.

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