BIOSENSOR

• US 20140081105A1
• Filed: 04/18/2012
• Published: 03/20/2014
• Est. Priority Date: 04/18/2011
• Status: Active Grant

• Current Assignee: WMC Group LLC
• Original Assignee: Noviosense B.V.
• Inventors: Hanssen, Johannes Hendrikus Leonardus, Tweehuysen, Robert
• Granted Patent: US 10,631,769 B2
• Time in Patent Office: Days
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08K 9/04 Ingredients treated with organic substances treated with macromolecular compounds C08K9/08
• CPC Class Codes: C09C 1/00 Treatment of specific inorganic materials other than fibrous fillers tenebrescent materials C09K9/00; luminescent materials C09K11/00; Preparation of carbon black
• CPC Class Codes: C12Q 1/005 involving specific analytes or enzymes including groups of enzymes, e.g. oxydases; C12Q1/004 takes precedence
• CPC Class Codes: C12Q 1/26 involving oxidoreductase
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 2800/042 Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
• CPC Class Codes: Y10T 29/49117 Conductor or circuit manufacturing

Abstract

A biosensor having a hollow coil having wires coiled in parallel and an electronic circuit component operably connected to the coil, wherein the wires include at least a first coiled wire which may be used as a counter electrode, a second coiled wire which may be used as a working electrode and a third coiled wire which may be used as a reference electrode, wherein the second coiled wire is provided with a biocompatible layer having a bioreceptor, wherein the electronic circuit component is capable of generating an input signal for a transceiver based upon the activity of the bioreceptor and wirelessly sending the input signal to the transceiver, wherein the electronic circuit component is encapsulated in a biocompatible resin.

Claims

1. A biosensor, comprising:

a hollow coil comprising wires coiled in parallel and an electronic circuit component operably connected to the coil,

wherein the wires include at least a first coiled wire which is used as a counter electrode, a second coiled wire which is used as a working electrode and a third coiled wire which is used as a reference electrode,

wherein the second coiled wire is provided with a biocompatible layer comprising a bioreceptor,

wherein the electronic circuit component is capable of generating an input signal for a transceiver based upon the activity of the bioreceptor and wirelessly sending the input signal to the transceiver and

wherein the electronic circuit component is encapsulated in a biocompatible resin.

2. The sensor according to claim 1, wherein the second coiled wire has a Pt surface.

3. The sensor according to claim 1, wherein the biocompatible layer comprising the bioreceptor is electroconductive.

4. The sensor according to claim 3, wherein the biocompatible layer comprises an electron conductive polymer synthesised from an optionally substituted five-membered heterocycle of formula (I)

5. The sensor according to claim 1, wherein the coil is encapsulated in a top layer of a biocompatible material.

6. The sensor according to claim 5, wherein the biocompatible material is a hydrophilic material.

7. The sensor according to claim 6, wherein the hydrophilic material is chosen from the group consisting of:

a copolymer of a hydrophobic reactive monomer and a hydrophilic reactive monomer;

a block co-polymer of polyethers wherein each block differs by at least one carbon in an aliphatic region and a homopolyer of a polysaccharide.

8. The sensor according to claim 1, wherein the biocompatible resin is a UV curable medical adhesive.

9. The sensor according to claim 1, wherein the third coiled wire is a silver/silver chloride reference electrode.

10. The sensor according to claim 1, wherein the wires further include a fourth coiled wire coated with an insulating layer which may be used as an antenna.

11. The sensor according to claim 1, wherein the wires further include a fifth coiled wire coated with an insulating layer which may be used as a spacer.

12. The sensor according to claim 10, wherein the insulating layer is made of parylene;

polytetrafluoro ethylene;

fluorinated ethylene propylene;

perfluoroxalkoxy copolymer;

polyphenylene sulfide;

polyether block amide;

polyether ketone;

poly amide;

polyimide;

polyesterimide;

polyethylene such as high-density polyethylene and low-density polyethylene;

polyvinylidene fluoride;

or a polyurethane or co-polymers thereof.

13. The sensor according to claim 1, comprising one or more further coiled wires provided with a biocompatible layer comprising a bioreceptor, which may be used as a further working electrode.

14. The sensor according to claim 1, wherein the bioreceptor is an oxidoreductase.

15. The sensor according to claim 1, wherein the bioreceptor is an oxidoreductase of enzyme commission groups EC 1.X.3 where X=1-17.

16. The sensor according to claim 1, wherein the bioreceptor is chosen from the group consisting of glucose oxidase, lactate dehydrogenase, pyruvate dehyrrogenase and pyruvate oxidase.

17. The sensor according to claim 1, wherein the sensor has a diameter of 0.1 to 3 mm.

18. The sensor according to claim 1, wherein the sensor has a length of 5 to 20 mm.

19. The sensor according to claim 1, wherein the electronic circuit component is attached at the end of the coil and the other end of the coil is provided with the biocompatible resin.

20. The sensor according to claim 1, wherein the sensor is encapsulated in a top layer of a biocompatible material.

21. A medical device comprising the sensor according to claim 1 and a remote receiver.

22. A process for making the sensor according to claim 1, comprising the steps of:

1) providing the hollow coil,

2) connecting the coil with the electric circuit component and

3) encapsulating the electric circuit component with a biocompatible resin.

23. A method, comprising the step of:

using the medical device of claim 21 for the measurement of glucose levels in an eye.

24. A method for diagnosing diabetes by using the sensor according to claim 1.