Microdialysis Sampling/Delivery Device

• US 20140081109A1
• Filed: 09/16/2013
• Published: 03/20/2014
• Est. Priority Date: 09/14/2012
• Status: Abandoned Application

• Current Assignee: Mehul J. Desai
• Original Assignee: Mehul J. Desai
• Inventors: DESAI, Mehul J.
• Application Number:
  US14/027,774
• Publication Number:
  US 20140081109A1
• Time in Patent Office: Days
• US Class Current: 600/366
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4566 Evaluating the spine A61B5/4561 takes precedence

Abstract

This present invention provides real-time in vivo sampling via ultra-small volume microdialysis of the intervertebral disc to assay single molecules of interest. The invention consists of three lumena, two that are capped with a membrane capable of sampling tissues via diffusion. A guide wire can provided between these two lumena so that they may be extended beyond the housing of the three lumena and directed via the guide wire. The third lumen can be utilized for injection or aspiration. Theoretically, agents including treatments such as stem cells or pharmaceutical agents may be introduced to the disc via this third lumen and the real-time effects may be assayed with the first two lumena. The three lumena may be placed adjacent to each other or in a concentric fashion to minimize the total size of the device.

Claims

1. A sampling device comprising:

an outer wall defining an outer enclosure having an internal space;

an inner wall defining an inner enclosure having an internal space, said inner wall positioned within the internal space of the outer enclosure;

a barrier extending within the internal space of the inner enclosure, the barrier defining a first lumen and a second lumen; and

,

a third lumen adjacent the first lumen and the second lumen, said third lumen positioned within the internal space of said outer wall.

2. The sampling device of claim 1, wherein the first lumen comprises an inflow lumen, the second lumen comprises an outflow lumen, and the third lumen comprises an injector lumen.

3. The sampling device of claim 1, wherein the first inner wall has a distal end, and further comprising a membrane coupled to the distal end of the first inner wall.

4. The sampling device of claim 3, wherein said barrier extends substantially parallel to the inner wall.

5. The sampling device of claim 4, wherein said barrier has a distal end, and further comprising a gap between the distal end of said barrier and the distal end of said first inner wall.

6. A sampling device comprising:

a first tube having an outer wall defining an internal space;

a second tube having an inner wall defining an internal space, the second tube located within the internal space of the first tube; and

,

a barrier located within the internal space of the second tube, the barrier defining a first lumen and a second lumen.

7. The sampling device of claim 6, further comprising a third lumen adjacent the first lumen and the second lumen.

8. The sampling device of claim 7, said third lumen located within the internal space of said first tube.

9. The sampling device of claim 6, wherein said sampling device is configured to detect a neurological response of an intervertebral disc.

10. The sampling device of claim 6, further comprising a membrane positioned over a distal end of said second tube.

11. The sampling device of claim 10, wherein said first lumen comprises an inflow lumen configured to carry a dialysate mixture or solute to said membrane, said membrane is configured to derive diffusion of a biological agent from a target tissue, and said second lumen comprises an outflow lumen configured to carry the diffused dialysate mixture or solute.

12. The sampling device of claim 11, wherein said target tissue comprises an intervertebral disc.

13. The sampling device of claim 6, wherein said second tube can move longitudinally with respect to said first tube, such that said second tube can extend outside said first tube.

14. A method for sampling an intervertebral disc of a patient utilizing a sampling device, the method comprising:

providing a dialysate mixture or solute in the sampling device; and

,

allowing a biological substance of the intervertebral disc to enter the sampling device and diffuse with the dialysate mixture or solute.

15. The method of claim 14, further comprising introducing through the sampling device, a medication or biologic agent to the intervertebral disc, the intervertebral disc providing biological substance that reacts thereto;

and allowing the reacting biological substance to enter the sampling device and diffuse with the dialysate mixture or solute.