Adapter and Drug Cartridge Alignment Device

• US 20140083517A1
• Filed: 09/23/2013
• Published: 03/27/2014
• Est. Priority Date: 09/27/2012
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics International AG (Roche Holding AG)
• Inventors: Moia, Franco, Kraft, Torsten, Kuster, Pius, Walther, Christoph
• Granted Patent: US 9,554,967 B2
• Time in Patent Office: Days
• US Class Current: 137/15.01
• CPC Class Codes: A61J 1/1406 Septums, pierceable membranes
• CPC Class Codes: A61J 1/1412 Containers with closing means, e.g. caps
• CPC Class Codes: A61J 1/20 Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• CPC Class Codes: A61M 39/10 Tube connectors; Tube couplings A61M39/02 takes precedence; connecting needles to syringes or hubs A61M5/34; connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: F04C 2270/041 Controlled or regulated
• CPC Class Codes: Y10T 137/0402 Cleaning, repairing, or assembling
• CPC Class Codes: Y10T 137/598 With repair, tapping, assembly, or disassembly means

Abstract

An alignment device for coupling a liquid drug cartridge with a longitudinal cartridge axis and a constricted neck portion with a cap and a piercable septum distal from the neck portion with an adapter is presented. The septum is perpendicular to the cartridge axis. The device comprises an adapter cannula with a longitudinal cannula axis to pierce the septum and a proximal cartridge engagement structure for axial aligned engagement with a distal end section of cartridge body. The device further comprises a distal adapter engagement structure for axial aligned engagement with the adapter. A coupling of the cartridge with the adapter is enabled via the alignment device. The adapter and the cartridge are, during the coupling, aligned by the cartridge engagement structure and the adapter engagement structure, respectively relative to each other such that the longitudinal cartridge axis and the longitudinal cannula axis form a common longitudinal axis.

Claims

1. An alignment device for coupling a liquid drug cartridge having an cartridge body extending along a longitudinal cartridge axis (Z) and, at its distal end, a constricted neck portion and a cap with a piercable septum perpendicular to the cartridge axis (Z) and distal from the neck portion;

and an adapter comprising an adapter cannula with a longitudinal cannula axis (Z′

) to pierce the septum and an infusion device coupler to mechanically couple to and engage with a housing of an ambulatory infusion device, the alignment device comprising;

a proximal cartridge engagement structure designed for axial aligned engagement with a distal end section of the cartridge body; and

a distal adapter engagement structure designed for axial aligned engagement with the adapter enabling a coupling of the cartridge with the adapter via the alignment device, wherein the adapter and the cartridge are, during the coupling, aligned by the cartridge engagement structure and the adapter engagement structure respectively relative to each other such that the longitudinal cartridge axis (Z) and the longitudinal cannula axis (Z′

) form a common longitudinal axis.

2. The alignment device according to claim 1, wherein the alignment device enables, during the coupling process, an aligned and guided relative displacement of the cartridge and the adapter towards each other along the common longitudinal axis.

3. The alignment device according to claim 1, wherein the cartridge engagement structure surrounds, in the assembled state, a distal section of the cartridge body and/or to project, in the assembled state, from the cap in a proximal direction.

4. The alignment device according to claim 1, wherein the cartridge engagement structure surrounds, in the assembled state, at least one of the neck portion and the cap.

5. The alignment device according to claim 1, wherein the adapter engagement structure has anti-rotation ribs to engage the adapter preventing a relative rotation between the adapter and the alignment device in the engaged state.

6. The alignment device according to claim 1, wherein the alignment device does not radially extend, in the assembled state, beyond the cartridge body.

7. The alignment device according to claim 1, wherein the alignment device has a general tubular shape extending along the common longitudinal axis.

8. The alignment device according to 7, wherein the alignment device comprises a proximal tubular member and a distal tubular member, wherein the proximal tubular member forms the cartridge engagement structure and the distal tubular member.

9. The alignment device according to 7, further comprises,

a proximal tubular member, and

a distal tubular member, wherein when comprising the adapter engagement structure, the proximal tubular member and the distal tubular member are arranged in a telescopic way and are axial guided displaceable with respect to each other along a common tube axis.

10. The alignment device according to claim 1, further comprises,

a cartridge block designed to prevent further relative displacement between the alignment device and the cartridge upon the cartridge block hitting the cartridge.

11. The alignment device according to claim 1, wherein the cartridge engagement structure and the adapter engagement structure overlap in an axial direction.

12. The alignment device according to claim 1, wherein the adapter engagement structure comprises at least one of a distal section of an outer circumferential surface of the alignment device, an inner circumferential surface of a distal section of the alignment device, and an alignment cavity formed in a distal front surface of the alignment device.

13. The alignment device according to claim 1, further comprising,

a venting member made from a hydrophobic and gas-permeable material and having an environment coupling surface and an opposed cartridge coupling surface that enables gas transfer and disables liquid transfer across the venting member between the environment coupling surface and the cartridge coupling surface, wherein the alignment device, when coupled to the cartridge, the cartridge has a movable wall, wherein the cartridge coupling surface fluidic couples to a no-liquid contacting outer surface of the movable wall, and wherein the environment coupling surface fluidic couples to the environment.

14. A cartridge kit, the cartridge kit comprising:

an alignment device according to claim 1; and

a liquid drug cartridge having a cartridge body extending along a longitudinal cartridge axis (Z) and having, at its distal end, a constricted neck portion, wherein the cartridge further comprises a cap with a piercable septum perpendicular to the cartridge axis (Z) and distal from the neck portion, and wherein the cartridge and the alignment device are coupled or designed to couple via the cartridge engagement structure.

15. An adapter kit, the adapter kit comprising:

an alignment device according to claim 1; and

an adapter, wherein the adapter comprises an adapter cannula with a longitudinal cannula axis (Z′

) to pierce a septum of a liquid drug cartridge and an infusion device coupler to mechanically couple to and engage with a housing of the ambulatory infusion device, and wherein the adapter and the alignment device are coupled or designed to couple via the adapter engagement structure.

16. A method for coupling a liquid drug cartridge having a cartridge body extending along a longitudinal cartridge axis (Z) and having, at its distal end, a constricted neck portion, wherein the cartridge further comprises a cap (115) with a piercable septum perpendicular to the cartridge axis (Z) and distal from the neck portion;

and an adapter comprising an adapter cannula with a longitudinal cannula axis (Z′

) to pierce the septum, the method comprising;

coupling the cartridge and the adapter via an alignment device according to claim 1.

17. A liquid drug cartridge for use in an ambulatory infusion device, the cartridge comprising:

a cartridge body extending along a longitudinal cartridge axis (Z);

a distal end section comprising a self-sealing, piercable septum perpendicular to the cartridge axis (Z); and

a number of alignment members distributed about an outer circumference of the cartridge body and extending along the longitudinal cartridge axis (Z).

18. The liquid drug cartridge according to claim 17, wherein the number of alignment members is three or four.