METHOD FOR TREATING INTRAOCULAR NEOVASCULAR DISEASES

• US 20140086934A1
• Filed: 02/28/2013
• Published: 03/27/2014
• Est. Priority Date: 10/21/2004
• Status: Abandoned Application

• Current Assignee: Genentech, Inc. (Roche Holding AG)
• Original Assignee: Genentech, Inc. (Roche Holding AG)
• Inventors: Shams, Naveed
• Application Number:
  US13/780,239
• Publication Number:
  US 20140086934A1
• Time in Patent Office: Days
• US Class Current: 424/158.1
• CPC Class Codes: A61K 2039/505 comprising antibodies
• CPC Class Codes: A61K 39/395 Antibodies agglutinins A61K38/36 ; as drug carriers A61K47/50; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears
• CPC Class Codes: C07K 16/22 against growth factors ; against growth regulators
• CPC Class Codes: C07K 2317/24 containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
• CPC Class Codes: C07K 2317/55 Fab or Fab'

Abstract

A method is provided for administering to a mammal suffering from, or at risk for, an intraocular neovascular disorder with regular dosing of a therapeutically effective amount of VEGF antagonist, followed by less frequent dosing of a therapeutically effective amount of VEGF antagonist.

Claims

1. A method for treating wet form age-related macular degeneration in a mammal, comprising the steps of:

a) administering to the mammal a number of first individual doses of an VEGF antagonist; and

b) administering to the mammal a number of second individual doses of the VEGF antagonist,

wherein the second individual doses are administered less frequently than the first individual doses.

2. The method of claim 1, wherein the mammal is a human.

3. The method of claim 1, wherein the administration is ocular.

4. The method of claim 3, wherein the administration is intraocular.

5. The method of claim 4, wherein the administration is intravitreal.

6. The method of claim 1, wherein the VEGF antagonist is an anti-VEGF antibody.

7. The method of claim 6, wherein the anti-VEGF antibody is a full length anti-VEGF antibody.

8. The method of claim 6, wherein the anti-VEGF antibody is an antibody fragment.

9. The method of claim 6, wherein the anti-VEGF antibody is a Fab antibody fragment.

10. The method of claim 8, wherein the antibody fragment is Y0317.

11. The method of claim 1, wherein the first individual doses are administered at one month intervals.

12. The method of claim 1, wherein the second individual doses are administered at three month intervals.

13. The method of claim 1, wherein the second individual doses are administered beginning three months after the number of first individual doses.

14. The method of claim 1, wherein the number of second individual doses are administered to the mammal during a period of at least 22 months following the number of first individual doses.

15. The method of claim 1, wherein the number of the first individual doses comprises about 3 individual doses.

16. The method of claim 1, wherein the number of the second individual doses comprises about 6 individual doses.

17. The method of claim 1, wherein the number of first individual doses and the number of second individual doses are administered over a time period of about 2 years.

18. The method of claim 1, wherein the first individual dose is administered at month 0, 1 and 2.

19. The method of claim 1, wherein the second individual dose is administered at month 5, 8, 11, 14, 17, 20 and 23.

20. The method of claim 1, wherein the first individual dose is administered at month 0, 1, and 2 and the second individual dose is administered at month 5, 8, 11, 14, 17, 20 and 23.

21. A method for treating intraocular neovascular disease, comprising:

administering to a mammal a number of first individual doses of an VEGF antagonist;

followed by,

administering to the mammal a number of second individual doses of the antagonist, wherein the second individual doses are administered less frequently than the first individual doses.