PRODUCT COMPRISING A NICOTINE-CONTAINING MATERIAL AND AN ANTI-CANCER AGENT

• US 20140088045A1
• Filed: 08/28/2013
• Published: 03/27/2014
• Est. Priority Date: 09/21/2012
• Status: Abandoned Application

• Current Assignee: Basil Rigas, Jason B. Rigas
• Original Assignee: Basil Rigas, Jason B. Rigas
• Inventors: Rigas, Basil, Rigas, Jason B.
• Application Number:
  US14/013,019
• Publication Number:
  US 20140088045A1
• Time in Patent Office: Days
• US Class Current: 514/81
• CPC Class Codes: A23G 4/068 containing plants or parts thereof, e.g. fruits, seeds, extracts containing gums A23G4/10
• CPC Class Codes: A23G 4/12 containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing dairy products A23G4/16
• CPC Class Codes: A24B 15/16 of tobacco substitutes
• CPC Class Codes: A24F 13/12 combined with other objects, e.g. writing utensils combined with walking or umbrella sticks A45B3/16
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/465 Nicotine; Derivatives thereof
• CPC Class Codes: A61K 31/6615 Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0058 Chewing gums non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00
• CPC Class Codes: A61K 9/007 Pulmonary tract; Aromatherapy
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/06 Inhaling appliances shaped like cigars, cigarettes or pipes
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 25/34 Tobacco-abuse
• CPC Class Codes: A61P 29/00 : Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 35/00 : Antineoplastic agents
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides a composition comprising a nicotine-containing material and an anti-cancer agent usable in the treatment and/or prevention or reduction of the risk of cancer and precancerous conditions as well as for preventing or reducing the risk of cancer recurrence. Furthermore, a composition comprising a nicotine-containing material and an anti-inflammatory agent usable in the treatment and/or prevention or reduction of the risk of inflammation, is provided. The nicotine containing composition can also include both an anti-cancer agent and an anti-inflammatory agent A device for administering the composition of the present invention to subjects can be a cigarette, smoking pipe, smokeless tobacco, electronic cigarette, transdermal patch or the like.

Claims

1. A composition comprising

a nicotine-containing material;

and

an agent comprising at least one of an anti-cancer agent, an anti-inflammatory agent, or a combination thereof.

2. The composition according to claim 1, wherein the agent comprises a phospho-NSAID.

3. The composition according to claim 1, wherein the agent comprises a compound selected from the group consisting of

4. The composition according to claim 1, wherein the agent comprises a compound selected from the group consisting of

5. The composition according to claim 1, wherein the agent comprises an anti-cancer agent and an anti-inflammatory agent.

6. The composition according to claim 1, wherein the agent comprises at least two anti-cancer agents.

7. The composition according to claim 1, wherein the agent comprises at least two anti-inflammatory agents.

8. The composition according to claim 5, wherein the agent comprises phospho-NSAID and curcumin.

9. The composition according to claim 1, wherein the nicotine-containing material is tobacco leaf.

10. The composition according to claim 1, wherein the composition contains nicotine and the agent in the ratio of from 1000:

1 to 1;

10 (wt;

wt).

11. The composition according to claim 1, wherein the composition is provided in the form of a smoking device selected from the group consisting of cigarette, cigar and smoking pipe.

12. The composition according to claim 11, wherein the smoking device includes a unit which renders the agent suitable for inhalation.

13. The composition according to claim 1, wherein the composition is a smoking cessation product.

14. The composition according to claim 1, wherein the composition is in the form of a transdermal patch.

15. The composition according to claim 11, wherein the smoking device is an inhalation device.

16. The composition according to claim 15, wherein the device is an electronic cigarette.

17. The composition according to claim 1, wherein the composition is an orally applied product.

18. The composition according to claim 17, wherein the product is a smokeless tobacco product.

19. A method for preventing or reducing the risk of inflammation comprising:

administering an effective amount of an anti-inflammatory agent, and a source of nicotine to a subject.

20. The method of claim 19 wherein the anti-inflammatory agent is administered simultaneously with the source of nicotine.

21. The method of claim 19 wherein the anti-inflammatory agent is administered sequentially with the source of nicotine.

22. The method of claim 19 wherein the step of administration is by inhalation of the anti-inflammatory agent and tobacco smoke.

23. A method for treating inflammation, comprising:

administering an effective amount of an anti-inflammatory agent, and a source of nicotine to a subject in need thereof.

24. The method of claim 23 wherein the anti-inflammatory agent is administered simultaneously with the source of nicotine.

25. The method of claim 23 wherein the anti-inflammatory agent is administered sequentially with the source of nicotine.

26. The method of claim 23 wherein the step of administration is by inhalation of the anti-inflammatory agent and tobacco smoke.

27. A method for treating inflammatory conditions, comprising:

administering an effective amount of an anti-inflammatory agent, and a source of nicotine to a subject in need thereof.

28. The method of claim 27 wherein the anti-inflammatory agent is administered simultaneously with the source of nicotine.

29. The method of claim 27 wherein the anti-inflammatory agent is administered sequentially with the source of nicotine.

30. The method of claim 2275 wherein the step of administration is by inhalation of the anti-inflammatory agent and tobacco smoke.

31. A method for preventing or reducing the risk of cancer comprising:

administering an effective amount of an anti-cancer agent, and a source of nicotine to a subject.

32. The method of claim 31 wherein the anti-cancer agent is administered simultaneously with the source of nicotine.

33. The method of claim 31 wherein the anti-cancer agent is administered sequentially with the source of nicotine.

34. The method of claim 31 wherein the step of administration is by inhalation of the anti-cancer agent and tobacco smoke.

35. A method for treating a cancer, comprising:

administrating an effective amount of an anti-cancer, and a source of nicotine to a subject in need thereof.

36. The method of claim 35 wherein the anti-cancer agent is administered simultaneously with the source of nicotine.

37. The method of claim 35 wherein the anti-cancer agent is administered sequentially with the source of nicotine.

38. The method of claim 35 wherein the step of administration is by inhalation of the anti-cancer agent and tobacco smoke.

39. A method for treating lung cancer, comprising:

administering an effective amount of an anti-cancer agent, and a source of nicotine to a subject in need thereof.

40. The method of claim 39 wherein the anti-cancer agent is administered simultaneously with the source of nicotine.

41. The method of claim 39 wherein the anti-cancer agent is administered sequentially with the source of nicotine.

42. The method of claim 39 wherein the step of administration is by inhalation of the anti-cancer agent and tobacco smoke.

43. A dispensing device for dispensing nicotine and a vaporized drug, comprising:

a tube having a first end adapted to receive a cigarette;

said tube having a heater for accepting a drug to be vaporized; and

a second end adapted to emit cigarette smoke and vaporized drug when suction force is applied by a user.

44. The dispensing device according to claim 43, further comprising a drug magazine which holds a plurality of drug containing solid carriers formulated as a capsule, tablet or pellet.

45. The dispensing device according to claim 43, wherein the drug containing solid carriers have a cylindrical shape.

46. The dispensing device according to claim 43, wherein the device is separable along its length to permit removal and replacement of the drug magazine.

47. The dispensing device according to claim 43, wherein the drug magazine is in the form of a circular ring, and wherein the plurality of drug containing solid carriers are arranged in a circumferential slot arranged near the outside of the circular ring.

48. The dispensing device according to claim 43, wherein the drug magazine includes a biasing element to bias the drug containing solid carriers toward a select location along the circular ring.

49. The dispensing device according to claim 43, wherein the dispensing device further includes an electronic control board for controlling the operation of the heater.

50. The dispensing device according to claim 43, wherein the dispensing device includes a battery chamber along its length for receiving a battery used to energize the electronic control board and heater.

51. The dispensing device according to claim 43, wherein the battery is in the form of a single cylinder, and wherein the device defines a hollow passageway alongside the battery for passage of cigarette smoke and vaporized drug.

52. The dispensing device according to claim 43, wherein the dispensing device further includes an electronic control board for controlling the maximum amount of drug that can be dispensed during a period of time.

53. The dispensing device according to claim 43, wherein the device includes a loading mechanism, engaged when the tube receives a cigarette, which loads a drug containing solid carriers into the heater.

54. The dispensing device according to claim 43, wherein the battery is in the form of a plurality of cylinders, and wherein the cylinders are spaced to provide hollow passageways for passage of cigarette smoke and vaporized drug.

55. The dispensing device according to claim 43, wherein the battery is in the form of a cylinder with a hollow core, to define a hollow passageway for passage of cigarette smoke and vaporized drug.

56. The dispensing device according to claim 43, wherein the device includes a transparent window surrounding the drug magazine to see the drug containing solid carriers from outside the device.

57. The dispensing device according to claim 43, wherein the device includes a display for displaying indicia indicating the number of drug containing solid carriers used from the magazine.

58. The dispensing device according to claim 43, wherein the device includes a display for displaying indicia indicating the number of drug containing solid carriers in the magazine.

59. The dispensing device according to claim 43, wherein the device includes an electric timer.

60. The dispensing device according to claim 59, wherein the timer has a time of day clock.

61. The dispensing device according to claim 59, wherein the timer detects the time between successive dispensing of the drug.

62. A drug magazine for holding a plurality of drug containing solid carriers comprising:

a circular ring defining a circumferential slot arranged near the outside of the circular ring, wherein the slot is adapted to receive a plurality of drug containing solid carriers.

63. The magazine of claim 62, further including a biasing element which biases the drug containing solid carriers to a selected location along the circular ring for dispensing.

64. The magazine of claim 62, wherein the biasing element is an elongated spring held in compression in the circular ring.

65. A pipe for dispensing nicotine and a vaporized drug, comprising:

a tobacco receiving chamber for receiving tobacco to be combusted;

a heater for receiving a drug and heating the drug to a temperature for vaporizing the drug; and

a pipe stem ending in a mouthpiece and having a passageway for passage of smoke from combusted tobacco and vaporized drug.

66. The pipe of claim 65, further including a port in the chamber for inserting a drug into the heater.

67. The pipe of claim 65, wherein the port has a door.

68. The pipe of claim 65, wherein the pipe includes a control board and battery for providing and controlling energy to the heater to vaporize the drug.

69. The pipe of claim 65, wherein the pipe includes a control board for providing in a visual display the amount of drug used in a given period of time.

70. The pipe of claim 65, wherein the pipe includes a control board for preventing the addition of drug to the pipe beyond a given amount for a given period of time.