DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS
First Claim
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1. A compound having a first, a second, and a third portion, wherein the second portion has the following structure:
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Accused Products
Abstract
This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.
38 Citations
61 Claims
- 1. A compound having a first, a second, and a third portion, wherein the second portion has the following structure:
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7-20. -20. (canceled)
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21. An array comprising a nucleic acid attached to a solid surface, wherein the nucleic acid comprises a methylazido group attached to a 3′
- O atom thereof and a molecule having the structure;
- O atom thereof and a molecule having the structure;
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22-53. -53. (canceled)
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54. A method for determining the identity of each of a series of consecutive nucleotide residues in a nucleic acid comprising:
a) contacting the nucleic acid with (i) at least four different deoxynucleotide triphosphate (dNTP) analogues, each having the structure; - View Dependent Claims (55, 56, 57, 58, 59, 60)
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61-76. -76. (canceled)
Specification