SYSTEM AND METHOD FOR IN VIVO MEASUREMENT OF BIOLOGICAL PARAMETERS

• US 20140094666A1
• Filed: 09/28/2012
• Published: 04/03/2014
• Est. Priority Date: 09/28/2012
• Status: Abandoned Application

• Current Assignee: Elfi-Tech Ltd
• Original Assignee: Elfi-Tech Ltd
• Inventors: FINE, Ilya
• Application Number:
  US13/629,752
• Publication Number:
  US 20140094666A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/0265 using electromagnetic means, e.g. electromagnetic flowmeter
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence

Abstract

A system, method and medical tool are presented for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region. The measurement system comprises an illuminating system, a detection system, and a control system. The illumination system comprises at least one light source configured for generating partially or entirely coherent light to be applied to the target region to cause a light response signal from the illuminated region. The detection system comprises at least one light detection unit configured for detecting time-dependent fluctuations of the intensity of the light response and generating data indicative of a dynamic light scattering (DLS) measurement. The control system is configured and operable to receive and analyze the data indicative of the DLS measurement to determine the at least one desired parameter or condition, and generate output data indicative thereof.

Claims

1. A system for use in non-invasive in vivo determination of at least one desired parameter or condition of a subject having a scattering medium in a target region, said system comprising:

(i) an illuminating system including at least one source of partially or entirely coherent light to be applied to the target region in said subject;

(ii) a detection system including at least one light detection unit configured for collecting time-dependent fluctuations of the intensity of the light response and generating data indicative of the DLS measurement; and

,

(iii) a control system configured and operable to analyze the data indicative of the DLS measurement to determine said at least one desired parameter or condition, and generate output data indicative thereof.

2. The system of claim 1, wherein the data generated by the detection system is indicative of fluctuation dependent speckle pattern of the light response over a predetermined frequency interval.

3. The system of claim 2, wherein the control system is configured and operable for analyzing the received data by using temporal autocorrelation intensity analyzing or power spectrum analyzing.

4. The system of claim 1, wherein said control system is configured and operable for analyze the received data to reject low frequency component of the received data, and process high frequency components of the received data, thereby enabling elimination of motion artifacts.

5. The system of claim 1, comprising a controllably operated pressurizing assembly configured and operable to affect a change in a blood flow.

6. The system of claim 1 wherein said control system comprises:

a data acquisition utility responsive to the generated data coming from said detection system;

a modulating utility associated with said illuminating system;

a data processing and analyzing utility for analyzing data from said data acquisition utility and determine at least one hemorheological and blood chemical parameter;

a memory utility for storing coefficients required to perform predetermined calculation by said data processing and analyzing utility, and

an external information exchange utility configured to enable downloading of the processed information to an external user to display it.

7. The system of claim 6, comprising a controllably operated pressurizing assembly configured and operable to affect a change in a blood flow, the control system comprising a control utility associated with pressurizing assembly.

8. The system of claim 1, comprising fiber optics for collecting the light response signal and deriving it to said detection system.

9. The system of claim 1 wherein said illuminating system includes at least two light sources operable at different wavelength ranges.

10. The system of claim 1, wherein said illuminating system is adapted to produce light of red and near infrared spectral regions, enabling assessment of arterial blood oxygen saturation and/or blood hemoglobin determination.

11. The system of claim 5, configured and operable to create an intermittent blood stasis state by applying over systolic blood pressure to the subject, thereby enabling determination of red blood cell (RBC) aggregation.

12. The method of claim 1, wherein said at least one light source of the illumination system is coupled with a polarization unit enabling to create polarized electromagnetic signal in one preferable direction, and an entrance of at least one of detection units of the detection system is coupled with a polarization units such that the polarization unit enables only certain direction of pre-selected polarized radiation to be detected.

13. (canceled)

14. An optical method for use in determining in vivo hemorheological chemical and physiological parameters of a subject, the method comprising:

(i) applying partially or entirely coherent light to a subject region in said subject to cause a light response signal from the target region;

(ii) detecting fluctuation dependent speckle pattern of the light response signal over a predetermined frequency interval, and generating data indicative thereof,

(iii) processing the detected data by using temporal autocorrelation intensity analyzing or power spectrum analyzing; and

;

(iv) determining at least one desired parameter or condition of said subject from the time-fluctuation of a dynamic light scattering (DLS) signal.

15. The method of claim 14, comprising:

(i) rejecting low frequency component of the detected DLS signal by using high-pass filters; and

(ii) processing high frequency components to eliminate motion artifacts.

16. The method of claim 14, wherein said at least one parameter comprises at least one of the following;

blood viscosity, an average size of RBC aggregates, and blood coagulation properties.

17. The method of claim 14, comprising creating temporal blood flow cessation at the measurement region to measure a post-occlusion signal.

18. The method of claim 17, comprising analyzing the measured post-occlusion signal to determine blood plasma viscosity and a rate of RBC aggregation,

19. The method of claim 14, comprising illumination the target region with light of red and near infrared spectra, thereby enabling for measuring simultaneously said DLS signal at tow or more wavelengths to determine at least one of the following:

arterial blood oxygen saturation, blood hemoglobin concentration, and glucose concentration.

20. (canceled)

21. (canceled)