NONINVASIVELY MEASURING ANALYTE LEVELS IN A SUBJECT
First Claim
1. A physiological monitoring system for determining a glucose level using an optical sensor, the system comprising:
- a non-invasive reflective optical sensor configured to irradiate biological tissue using a beam of light; and
a physiological monitor comprising at least one processor, the physiological monitor configured to;
obtain scattering measurements of light from the beam reflected by the biological tissue;
identify portions of the measurements of the light corresponding to measurements taken within one or more blood vessels within the biological tissue; and
estimate the glucose level based at least partly on the measurements taken within the one or more blood vessels.
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Accused Products
Abstract
A method for noninvasively measuring analyte levels includes using a non-imaging OCT-based system to scan a two-dimensional area of biological tissue and gather data continuously during the scanning. Structures within the tissue where measured-analyte-induced changes to the OCT data dominate over changes induced by other analytes are identified by focusing on highly localized regions of the data curve produced from the OCT scan which correspond to discontinuities in the OCT data curve. The data from these localized regions then can be related to measured analyte levels.
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Citations
27 Claims
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1. A physiological monitoring system for determining a glucose level using an optical sensor, the system comprising:
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a non-invasive reflective optical sensor configured to irradiate biological tissue using a beam of light; and a physiological monitor comprising at least one processor, the physiological monitor configured to; obtain scattering measurements of light from the beam reflected by the biological tissue; identify portions of the measurements of the light corresponding to measurements taken within one or more blood vessels within the biological tissue; and estimate the glucose level based at least partly on the measurements taken within the one or more blood vessels. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A physiological monitoring system for determining a glucose level using an optical sensor, the system comprising:
a physiological monitor comprising at least one processor, the physiological monitor configured to; obtain measurements of reflected light detected by a non-invasive reflective optical sensor from a beam of light generated by the reflective sensor and reflected from biological tissue, the beam of light comprising two or more wavelengths selected to differentiate glucose from another biological constituent based on scattering properties of the beam; generate light scatter measurements based at least partly on the measurements of the reflected light from the beam of light; process the light scatter measurements to determine the glucose level of the biological tissue based at least partly on identifying glucose from the light scatter measurements. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method of measuring glucose concentration within biological tissue, the method comprising:
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generating a beam of light, the beam comprising two or more wavelengths selected to differentiate glucose from another biological constituent based on scattering properties of the beam; and illuminating biological tissue with the beam; generating light scatter measurements based at least partly on light from the beam reflected by the illuminated biological tissue; and processing the light scatter measurements to determine a glucose level of the biological tissue based at least partly on identifying glucose based on the scattering properties of the beam. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification