ZWITTERION SURFACE MODIFICATIONS FOR CONTINUOUS SENSORS
First Claim
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1. A device for measurement of an analyte concentration, the device comprising:
- a sensor configured to generate a signal associated with a concentration of an analyte; and
a sensing membrane located over the sensor, the sensing membrane comprising a diffusion resistance domain configured to control a flux of the analyte therethrough, wherein the diffusion resistance domain comprises a base polymer and one or more zwitterionic compounds, and wherein the base polymer comprises both hydrophilic and hydrophobic regions.
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Abstract
Devices are provided for measurement of an analyte concentration, e.g., glucose in a host. The device can include a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor. The sensing membrane comprises a diffusion resistance domain configured to control a flux of the analyte therethrough. The diffusion resistance domain comprises one or more zwitterionic compounds and a base polymer comprising both hydrophilic and hydrophobic regions.
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34 Claims
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1. A device for measurement of an analyte concentration, the device comprising:
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a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor, the sensing membrane comprising a diffusion resistance domain configured to control a flux of the analyte therethrough, wherein the diffusion resistance domain comprises a base polymer and one or more zwitterionic compounds, and wherein the base polymer comprises both hydrophilic and hydrophobic regions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A device for measurement of an analyte concentration, the device comprising:
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a sensor configured to generate a signal associated with a concentration of an analyte; and a sensing membrane located over the sensor, wherein a surface of the sensing membrane most distal to the sensor is coated with a coating comprising one or more zwitterionic compounds. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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Specification