BIODEGRADABLE IRON-CONTAINING COMPOSITIONS, METHODS OF PREPARING AND APPLICATIONS THEREFOR

• US 20140097277A1
• Filed: 10/03/2013
• Published: 04/10/2014
• Est. Priority Date: 10/05/2012
• Status: Active Grant

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Inventors: KUMTA, PRASHANT N., CHUNG, SUNG JAE, SAHA, PARTHA, VELIKOKHATNYI, OLEG, DATTA, MONI KANCHAN, HONG, DAE HO, CHOU, DA-TREN
• Granted Patent: US 11,376,349 B2
• Time in Patent Office: Days
• US Class Current: 241/15
• CPC Class Codes: A61L 31/022 Metals or alloys
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C22C 33/10 including procedures for adding magnesium
• CPC Class Codes: C22C 38/00 Ferrous alloys, e.g. steel alloys cast-iron alloys C22C37/00
• CPC Class Codes: C22C 38/002 containing In, Mg, or other elements not provided for in one single group C22C38/001 - C22C38/60
• CPC Class Codes: C22C 38/14 containing titanium or zirconium
• CPC Class Codes: C22C 45/02 with iron as the major constituent

Abstract

The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular.

Claims

1. A biodegradable metal alloy-containing composition, comprising:

elemental iron; and

one or more elements selected from the group consisting of manganese, magnesium, zinc, zirconium and calcium.

2. The composition of claim 1, wherein the one or more elements are manganese, magnesium and calcium.

3. The composition of claim 1, wherein the one or more elements are magnesium, zirconium and calcium.

4. The composition of claim 1, wherein the one or more elements are magnesium, zinc and calcium.

5. The composition of claim 1, wherein the elemental iron is present in an amount such that it constitutes from about 10.0 weight percent to about 95.0 weight percent based on total weight of the composition.

6. The composition of claim 2, wherein the manganese, magnesium and calcium are each present in an amount such that the manganese constitutes from about 5.0 weight percent to about 75.0 weight percent, the magnesium constitutes from greater than zero weight percent to about 10.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 10.0 weight percent, based on total weight of the composition.

7. The composition of claim 3, wherein the magnesium, zirconium and calcium are each present in an amount such that the magnesium constitutes from greater than zero weight percent to about 7.0 weight percent, the zirconium constitutes from about 8.0 weight percent to about 52.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 30.0 weight percent, based on total weight of the composition.

8. The composition of claim 4, wherein the magnesium, zinc and calcium are each present in an amount such that the magnesium constitutes from greater than zero weight percent to about 10.0 weight percent, the zinc constitutes from greater than zero weight percent to about 10.0 weight percent, and the calcium constitutes from greater than zero weight percent to about 30.0 weight percent, based on total weight of the composition.

15. A biodegradable medical device comprising the composition of claim 1.

16. The biodegradable medical device of claim 15, further comprising implanting the device in a body of a patent for use in applications selected from the group consisting of orthopedic, craniofacial and cardiovascular.

17. The biodegradable medical device of claim 15, wherein said device is selected from the group consisting of plate, mesh, staple, screw, pin, tack, rod, suture anchor, tubular mesh, coil, x-ray marker, catheter, pipe, shield, bolt, clip, plug, dental implant, graft device, endoprosthesis, bone-fracture healing device, bone replacement device, joint replacement device, tissue regeneration device, cardiovascular stent, nerve guide, surgical implant, surgical wire and combinations thereof.

9. A method of preparing a biodegradable, metal alloy-containing composition, comprising:

charging in a high energy mill elemental iron and one or more elements selected from the group consisting of manganese, magnesium, zirconium, zinc and calcium; and

conducting high energy milling of the elemental iron and one or more elements.

10. The method of claim 9 wherein the high energy milling is conducted in dry conditions followed by high energy milling conducted in wet conditions.

11. The method of claim 9, wherein material resulting from the high energy milling is subjected to a casting process to form an iron alloy-containing cast.

12. The method of claim 11, further comprising finishing the iron alloy-containing cast to produce a biomedical device.

13. The method of claim 12, wherein the biomedical device is implanted into a body of a patient.

14. The method of claim 13, wherein the biomedical device dissolves in the body of the patient.

18. The composition of claim 9, wherein the one or more elements are manganese, magnesium and calcium.

19. The composition of claim 9, wherein the one or more elements are magnesium, zirconium and calcium.

20. The composition of claim 9, wherein the one or more elements are magnesium, zinc and calcium.