OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF
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Abstract
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
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Citations
258 Claims
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1-238. -238. (canceled)
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239. A compound comprising:
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a modified oligonucleotide consisting of 10 to 20 linked nucleosides, wherein the modified oligonucleotide comprises; a 5′
-wing consisting of 2 to 5 linked nucleosides;a 3′
-wing consisting of 2 to 5 linked nucleosides; anda gap between the 5′
-wing and the 3′
-wing consisting of 6 to 14 linked 2′
-deoxynucleosides; andwherein at least one of the 5′
-wing or the 3′
-wing comprises at least one bicyclic nucleoside;
at least one of the 5′
-wing and the 3′
-wing comprises at least one 2′
-substituted nucleoside;
wherein one of the 5′
-wing or the 3′
-wing comprises at least one 2′
-deoxynucleoside; andwherein the nucleobase sequence of the modified oligonucleotide is complementary to the nucleobase sequence of a target nucleic acid. - View Dependent Claims (240, 241, 242, 243, 244, 245, 246, 247, 248, 249, 250, 251, 252, 253, 254, 255, 256, 257, 258)
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Specification