In-vitro Calibration Of An Ophthalmic Analyte Sensor
First Claim
1. A method comprising:
- receiving an indication of a calibration-solution sensor measurement obtained from an eye-mountable device exposed to a calibration solution, wherein the eye-mountable device includes an electrochemical sensor with a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte, and wherein the eye-mountable device is configured to obtain a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed;
determining a calibration value based on at least the calibration-solution measurement and an analyte concentration of the calibration solution;
receiving an indication of a tear-film sensor measurement obtained from the eye-mountable device exposed to tear film; and
determining a concentration of the analyte in the tear film based on at least the tear-film sensor measurement and the calibration value.
2 Assignments
0 Petitions
Accused Products
Abstract
An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. A calibration-solution measurement is obtained while the eye-mountable device is exposed to a calibration solution. A calibration value is determined based on at least the calibration-solution measurement and an analyte concentration of the calibration solution. A tear-film measurement is obtained while the eye-mountable device is mounted to an eye so as to be exposed to tear film. The analyte concentration of the tear film is determined based on at least the tear-film measurement and the calibration value.
-
Citations
20 Claims
-
1. A method comprising:
-
receiving an indication of a calibration-solution sensor measurement obtained from an eye-mountable device exposed to a calibration solution, wherein the eye-mountable device includes an electrochemical sensor with a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte, and wherein the eye-mountable device is configured to obtain a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed; determining a calibration value based on at least the calibration-solution measurement and an analyte concentration of the calibration solution; receiving an indication of a tear-film sensor measurement obtained from the eye-mountable device exposed to tear film; and determining a concentration of the analyte in the tear film based on at least the tear-film sensor measurement and the calibration value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. A system comprising:
-
an eye-mountable device comprising; a transparent polymeric material having a concave surface and a convex surface, wherein the concave surface is configured to be removably mounted over a corneal surface and the convex surface is configured to be compatible with eyelid motion when the concave surface is so mounted; an antenna; an electrochemical sensor that includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte; a controller electrically connected to the electrochemical sensor and the antenna, wherein the controller is configured to (i) control the electrochemical sensor to obtain a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed and (ii) use the antenna to indicate the sensor measurement; and a reader operable in a calibration mode and a measurement mode, wherein in the calibration mode the reader is configured to (i) wirelessly communicate with the antenna to receive a calibration-solution sensor measurement obtained with the eye-mountable device exposed to a calibration solution, (ii) determine a calibration value based on at least the calibration-solution sensor measurement and an analyte concentration of the calibration solution, and (iii) store the calibration value in a memory, and wherein in the measurement mode the reader is configured to (i) wirelessly communicate with the antenna to receive a tear-film sensor measurement obtained with the eye-mountable device exposed to a tear film and (ii) determine a concentration of the analyte in the tear film based on at least the tear-film sensor measurement and the calibration value. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A non-transitory computer readable medium storing instructions that, when executed by one or more processors in a computing device, cause the computing device to perform operations, the operations comprising:
-
receiving an indication of a calibration-solution sensor measurement obtained from an eye-mountable device exposed to a calibration solution, wherein the eye-mountable device includes an electrochemical sensor with a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte, and wherein the eye-mountable device is configured to obtain a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed; determining a calibration value based on at least the calibration-solution measurement and an analyte concentration of the calibration solution; receiving an indication of a tear-film sensor measurement obtained from the eye-mountable device exposed to tear film; and determining a concentration of the analyte in the tear film based on at least the tear-film sensor measurement and the calibration value. - View Dependent Claims (19, 20)
-
Specification