Nozzle For The Supply of Biological Material, In Particular Cells, Medical Device With Such A Nozzle, Use Of A Nozzle, Method For Mixing Fluids And Apparatus

• US 20140107620A1
• Filed: 10/15/2013
• Published: 04/17/2014
• Est. Priority Date: 10/16/2012
• Status: Active Grant

• Current Assignee: Erbe Elektromedizin GmbH (C. Erbe GmbH)
• Original Assignee: Erbe Elektromedizin GmbH (C. Erbe GmbH)
• Inventors: Fischer, Klaus, Enderle, Markus, Fech, Andreas, Szyrach, Mara
• Granted Patent: US 9,878,126 B2
• Time in Patent Office: Days
• US Class Current: 604/518
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61B 2017/00522 Sprayers
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
• CPC Class Codes: A61M 25/0067 characterised by the distal end, e.g. tips A61M25/0054, A61M25/04 take precedence; balloon catheters A61M25/10
• CPC Class Codes: B01F 25/10 Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
• CPC Class Codes: B01F 33/26 Mixers with an endless belt for transport of the material, e.g. in layers or with mixing means above or at the end of the belt
• CPC Class Codes: B05B 1/3426 the channels emerging in the swirl chamber perpendicularly to the outlet axis B05B1/3436 takes precedence
• CPC Class Codes: B05B 1/3436 the interface being a plane perpendicular to the outlet axis
• CPC Class Codes: B05B 1/3442 the interface being a cone having the same axis as the outlet
• CPC Class Codes: B05B 7/0483 with gas and liquid jets intersecting in the mixing chamber
• CPC Class Codes: B05B 7/10 producing a swirling discharge

Abstract

A nozzle for the supply of biological material, in particular tissue cells, having a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), at least one nozzle opening (23) which is formed in the distal end surface (22), and at least two supply ducts (30, 40, 50) which discharge into the mixing chamber (11). A first supply duct (30) is arranged in the proximal end surface (21) and discharges into the mixing chamber (11) coaxially to the nozzle opening (23) and a second supply duct (40) has an inlet opening (42) which discharges into the mixing chamber (11) laterally, in particular tangentially at the distal end surface (22).

Claims

1. Nozzle for the supply of biological material comprising:

a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21),

at least one nozzle opening (23) which is formed in the distal end surface (22),

at least two supply ducts (30, 40, 50) which discharge into the mixing chamber (11),

a first supply duct (30) is arranged in the proximal end surface (21) and configured to discharge into the mixing chamber (11) coaxially to the nozzle opening (23), and

a second supply duct (40) including an inlet opening (42) which discharges into the mixing chamber (11) laterally and tangentially at the distal end surface (22).

2. Nozzle according to claim 1, wherein the mixing chamber (11) has a length L which is at most 500 μ

m.

3. Nozzle according to claim 1, wherein the lateral inlet opening (42) has a depth T which corresponds to length L of the mixing chamber (11).

4. Nozzle according to claim 1, wherein the distal end surface (22) of the mixing chamber (11) is arranged perpendicular to a longitudinal axis of the second supply duct (40).

5. Nozzle according to claim 1, wherein the lateral inlet opening (42) has a rectangular cross-sectional profile and/or tapers in the direction of the mixing chamber (11).

6. Nozzle according to claim 5, wherein the lateral inlet opening (42) has in particular two curved lateral surfaces (43, 44) which converge at the mixing chamber (11).

7. Nozzle according to claim 6, wherein an outer lateral surface (43) of the lateral inlet opening (42) forms a continuous transition into an inner circumferential surface (12) of the mixing chamber (11).

8. Nozzle according to claim 1, further comprising

at least one third supply duct (50) with a further lateral inlet opening (52), which discharges laterally into the mixing chamber (11) at the distal end surface (22).

9. Nozzle according to claim 1, wherein the supply ducts (30, 40, 50) and/or the mixing chamber (11) and/or the nozzle opening (23) are formed in one piece or several pieces.

10. Nozzle according to claim 1, wherein the supply ducts (30, 40, 50) are formed in a duct carrier (60) and/or the nozzle opening (23) is formed in a nozzle plate (20), wherein the mixing chamber (11) is formed in the nozzle plate (20) or in a mixing chamber plate (10) which is arranged between the nozzle plate (20) and the duct carrier (60).

11. Nozzle according to claim 1, further comprising

at least one temperature control duct (90) configured to provide temperature control for a fluid flowing through at least one supply duct (30, 40, 50), wherein the temperature control duct (90) connects a supply line and a return line in such a manner that a closed temperature control circuit is formed.

12. Nozzle according to claim 1, further comprising

at least an atomiser plate (80) connected distally to the nozzle plate (20) and having an atomiser opening (82) arranged coaxially to the nozzle opening (23), wherein at least one atomiser duct (81) is formed in the atomiser plate (80), connects the atomiser opening (82) to a gas supply duct (70) and preferably discharges tangentially into the atomiser opening (82).

13. Nozzle for medical purposes comprising:

a mixing chamber (11), which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), and

at least one nozzle opening (23) which is arranged in the distal end surface (22),

wherein the mixing chamber (11) has a substantially cylindrical inner contour with at least two inlet openings (42, 52) which discharge into the mixing chamber (11) laterally, and tangentially, which inlet openings (42, 52) are fluid-connected to a supply duct (40, 50), and

wherein the inlet openings (42, 52) have different or the same cross-sectional surfaces.

14. Nozzle according to claim 13, wherein the cross-sectional surface of the inlet opening (42, 52) is formed to be smaller than the cross-sectional surface of the supply line (30).

15. Nozzle according to claim 13 wherein a ratio of the cross-sectional surfaces of the inlet openings (42, 52) corresponds to a ratio of volumetric flows of at least two fluids which flow with different or same volumetric flows into the mixing chamber (11), so that the fluids flow into the mixing chamber (11) with a substantially same average entry speed.

16. Method for mixing at least two fluids by a nozzle for medical purposes, the method comprising:

receiving fluids flowing with different volumetric flows into a mixing chamber (11) delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21), with at least one nozzle opening (23) arranged in the distal end surface (22);

discharging the fluids via at least two inlet openings (42, 52) disposed in the mixing chamber'"'"'s (11) substantially cylindrical inner contour into the mixing chamber (11) laterally, and tangentially, and

wherein a ratio of cross-sectional surfaces of the inlet openings (42, 52) corresponds to a ratio of the volumetric flows so that the fluids flow into the mixing chamber (11) with a substantially same average entry speed.

17. (canceled)

18. Apparatus to which a surgical instrument for medical purposes can be connected, wherein the surgical instrument has a nozzle which comprises:

a mixing chamber (11) which is delimited by a proximal end surface (21) and a distal end surface (22) spaced apart from the proximal end surface (21),

at least one nozzle opening (23) which is formed in the distal end surface (22), and

at least two supply ducts (30, 40, 50) which discharge into the mixing chamber (11),

wherein the apparatus has an open-loop or closed-loop control unit,

wherein the fluid supply is controlled by the nozzle by the open-loop control unit.

19. Apparatus according to claim 18, wherein the open-loop control unit is configured to control a fluid to flow exclusively through a supply duct (40, 50) offset radially to the outside to effect a conical jet exit at the nozzle opening (23).

20. Apparatus according to claim 18, wherein the open-loop control unit is configured to control a fluid to flow exclusively through a coaxially arranged supply duct (30) to effect a full jet exit at the nozzle opening (23).

21. Apparatus according to claim 18, wherein the open-loop control unit is configured to control a fluid to flow both through a coaxially arranged supply duct (30) and a supply duct (40, 50) offset radially to the outside to amplify an effect of the conical jet on tissue to be treated.