ACTIVE LOADED FIXATION DEVICES
First Claim
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1. A method for producing a fixation device comprising an autologous cell concentrate from a physiological solution, wherein the method comprises:
- i) providing a physiological solution not previously subjected to centrifugation;
ii) subjecting the physiological solution to at least one filter to produce at least a first filter retentate and a first filter permeate solution, the first filter retentate comprising platelets, nucleated cells, or both, per unit volume greater than in the physiological solution, and wherein the first permeate solution comprises plasma and red blood cells;
iii) removing the first filter retentate from the filter to provide an autologous cell concentrate; and
iv) subjecting a fixation device to at least the first autologous cell concentrate.
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Abstract
The present disclosure relates to methods for producing, including intra-operatively obtaining, a fixation device, and fixation devices produced thereby, containing an autologous cell concentrate from a physiological solution, wherein the cell concentrate is isolated without the need for centrifugation.
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Citations
30 Claims
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1. A method for producing a fixation device comprising an autologous cell concentrate from a physiological solution, wherein the method comprises:
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i) providing a physiological solution not previously subjected to centrifugation; ii) subjecting the physiological solution to at least one filter to produce at least a first filter retentate and a first filter permeate solution, the first filter retentate comprising platelets, nucleated cells, or both, per unit volume greater than in the physiological solution, and wherein the first permeate solution comprises plasma and red blood cells; iii) removing the first filter retentate from the filter to provide an autologous cell concentrate; and iv) subjecting a fixation device to at least the first autologous cell concentrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A fixation device substantially coated with an autologous cell concentrate comprising:
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i) a fixation device; ii) at least one component of the fixation device substantially coated with an autologous cell concentrate, the autologous cell concentrate comprising substantially platelets, nucleated cells, or both, and substantially no plasma or red blood cells, wherein the autologous cell concentrate has been prepared by subjecting a physiological solution to a filter to produce a filter retentate and a permeate solution, the filter retentate comprising platelets, nucleated cells, or both per unit volume greater than in the physiological solution, and wherein the permeate solution comprises plasma and red blood cells. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. An autologous cell concentrate coated suture comprising:
at least one strand of a suture substantially coated with an autologous cell concentrate comprising platelets, nucleated cells, or both. - View Dependent Claims (28, 29, 30)
Specification