ROUGHENED CUFF SURFACE

• US 20140107772A1
• Filed: 03/06/2013
• Published: 04/17/2014
• Est. Priority Date: 10/12/2012
• Status: Abandoned Application

• Current Assignee: St. Jude Medical Cardiology Division Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical Cardiology Division Incorporated (Abbott Laboratories Incorporated)
• Inventors: Li, XueMei, Alkhatib, Yousef F., Zhou, Zhengrong
• Application Number:
  US13/786,999
• Publication Number:
  US 20140107772A1
• Time in Patent Office: Days
• US Class Current: 623/2.17
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/2415 Manufacturing methods
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

A prosthetic heart valve includes a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end. A cuff having an inner surface and an outer surface is made sufficiently rough to promote tissue growth. The prosthetic heart valve further includes a collapsible and expandable valve assembly, the valve assembly including a plurality of leaflets connected to at least one of the stent and the cuff.

Claims

1. A prosthetic heart valve, comprising:

a collapsible and expandable stent having a proximal end and a distal end;

a cuff having an inner surface and an outer surface, at least a portion of the outer surface having a plurality of indentations capable of promoting tissue growth connected to at least one of the inner and outer surfaces of the stent;

a collapsible and expandable valve assembly, the valve assembly including a plurality of leaflets connected to at least one of the stent and the cuff.

2. The prosthetic heart valve of claim 1, wherein the plurality of indentations are uniformly distributed on the cuff.

3. The prosthetic heart valve of claim 1, wherein the indentations extend partially through the thickness of the cuff.

4. The prosthetic heart valve of claim 2, wherein the indentations extend fully through the thickness of the cuff.

5. The prosthetic heart valve of claim 1, wherein the outer surface of the cuff is rough at a microscopic level.

6. The prosthetic heart valve of claim 1, wherein the outer surface of the cuff is rough at a macroscopic level.

7. The prosthetic heart valve of claim 1, wherein the cuff is formed of a polymer.

8. The prosthetic heart valve of claim 7, wherein the polymer comprises polyurethane.

9. The prosthetic heart valve of claim 7, wherein the polymer comprises a silicone.

10. A method of treating a cuff for a prosthetic valve assembly comprising:

providing a collapsible and expandable stent having a proximal end and a distal end;

roughening at least a portion of an outer surface of a cuff to promote tissue growth on the roughened surface;

coupling the cuff to the collapsible and expandable stent.

11. The method of claim 10, wherein the cuff is coupled to the stent after the outer surface of the cuff has been roughened.

12. The method of claim 10, wherein roughening an outer surface of a cuff comprises forming indentations in the cuff at a macroscopic level.

13. The method of claim 10, wherein roughening an outer surface of a cuff comprises forming indentations in the cuff at a microscopic level.

14. The method of claim 10, wherein roughening an outer surface of a cuff comprises using at least one needle to puncture the cuff.

15. The method of claim 10, wherein roughening an outer surface of a cuff comprises using a thermal treatment to alter the outer surface of the cuff.

16. The method of claim 10, wherein roughening an outer surface of a cuff comprises using a surface coating technique to alter the outer surface of the cuff.

17. The method of claim 10, wherein roughening an outer surface of a cuff comprises using a chemical vapor deposition technique to roughen the cuff.

18. The method of claim 10, wherein roughening an outer surface of a cuff comprises using a gas to treat the surface and generate bioactive groups or chemical structures on the cuff.

19. The method of claim 10, wherein roughening an outer surface of a cuff comprises immobilization of biological molecules onto the cuff to promote tissue growth.

20. The method of claim 19, wherein immobilization of biological molecules comprises treating the cuff with growth factors.

21. The method of claim 10, wherein roughening an outer surface of a cuff comprises releasing biological molecules at a device-tissue interface to promote tissue growth.