BLOCK COPOLYMERS FOR STABLE MICELLES

• US 20140113879A1
• Filed: 09/16/2013
• Published: 04/24/2014
• Est. Priority Date: 04/11/2012
• Status: Abandoned Application

• Current Assignee: Intezyne Technologies
• Original Assignee: Intezyne Technologies
• Inventors: Carie, Adam, Sill, Kevin
• Application Number:
  US14/028,477
• Publication Number:
  US 20140113879A1
• Time in Patent Office: Days
• US Class Current: 514/34
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 47/645 Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
• CPC Class Codes: A61K 47/6907 the form being a microemulsion, nanoemulsion or micelle
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: C08G 65/2606 containing hydroxyl groups
• CPC Class Codes: C08G 65/2609 containing aliphatic hydroxyl groups
• CPC Class Codes: C08G 65/2627 containing aromatic or arylaliphatic amine groups
• CPC Class Codes: C08G 65/3324 cyclic
• CPC Class Codes: C08G 65/33303 containing amino group
• CPC Class Codes: C08G 65/33396 having oxygen in addition to nitrogen
• CPC Class Codes: C08G 69/10 Alpha-amino-carboxylic acids polysuccinimides C08G73/1092
• CPC Class Codes: C08G 69/40 Polyamides containing oxygen in the form of ether groups C08G69/12, C08G69/32 take precedence

Abstract

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.

Claims

1. A method for preparing a crosslinked, drug loaded micelle, said method comprising the steps of:

(a) providing a multiblock copolymer of formula I;