MEDICAMENT DELIVERY DEVICE WITH DISPENSE INTERFACE SENSOR AND METHOD CONTROLLING THE DEVICE

• US 20140114277A1
• Filed: 05/24/2012
• Published: 04/24/2014
• Est. Priority Date: 05/25/2011
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Eggert, Ilona, Langley, Christopher Nigel, Day, Shane Alistair
• Granted Patent: US 9,492,616 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2205/14 Detection of the presence or absence of a tube, a connector or a container in an apparatus
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/6018 providing set-up signals for the apparatus configuration
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/31576 Constructional features or modes of drive mechanisms for piston rods
• CPC Class Codes: A61M 5/34 Constructions for connecting the needle , e.g. to syringe nozzle or needle hub connecting catheter tubes to hubs A61M25/0014

Abstract

A medicament delivery device is shown for the administration of one or more drug agents. The device comprises a medicament cartridge retainer for holding a medicament cartridge. A dispense interface can be attached to an attachment of the device for facilitating fluidic communication from the device. Further, an interface sensor is configured to provide an output indicative of whether the dispense interface is attached to the attachment. The device also comprises a piston rod for driving a bung of the medicament cartridge, and a drive train for advancing the piston rod to the bung. A controller is configured to control the drive train to advance the piston rod towards the bung when the output of the interface sensor indicates that the dispense interface is not on the attachment. The controller is further configured to disable advancement of the piston rod when the output of the interface sensor indicates that the dispense interface is at least partially on the attachment.

Claims

1-15. -15. (canceled)

16. A medicament delivery device for the administration of one or more drug agents, the device comprising

a medicament cartridge retainer for holding a medicament cartridge,

an attachment for attachment thereto of a dispense interface, the dispense interface for providing an exit pathway for the medicament contained in the cartridge,

an interface sensor configured to provide an output indicative of whether the dispense interface is attached to the attachment,

a piston rod for driving a bung of the medicament cartridge, a drive train for advancing the piston rod to the bung,

a controller configured to control the drive train to advance the piston rod towards the bung when the output of the interface sensor indicates that the dispense interface is not on the attachment and to disable advancement of the piston rod when the output of the interface sensor indicates that the dispense interface is at least partially on the attachment,

wherein the controller is operative to sense stalling of the drive train, and

wherein the controller is further configured to stop the drive train when stalling of the drive train is sensed.

17. A medicament delivery device according to claim 16, wherein the controller is operative to monitor the output signal of the interface sensor during advancement of the piston rod and disable advancement of the piston rod if, during advancement thereof, the interface sensor indicates at least partial attachment of the dispense interface.

18. A medicament delivery device according to claim 16, wherein the stalling of the drive train occurs on contact between the piston rod and the bung.

19. A medicament delivery device according to claim 16, comprising an encoder associated with the drive train, the encoder for providing an output to the controller, wherein the stalling is sensed in dependence on the encoder output.

20. A medicament delivery device according to claim 19, wherein the controller is operative to determine the position of the bung by monitoring the encoder output.

21. A medicament delivery device according to claim 16 comprising first and second medicament cartridge retainers each for holding a medicament cartridge.

22. A medicament delivery device according to claim 21, wherein the dispense interface provides fluidic communication from the first and second medicament cartridge retainers to an outlet of the device.

23. A medicament delivery device according to claim 16, wherein the controller is operative to advance the piston rod following a cartridge change.

24. A medicament delivery device according to claim 16, wherein the device is hand-held.

25. A medicament delivery device according to claim 24, wherein the device is a pen-type injection device.

26. A medicament delivery device according to claim 16, wherein the interface sensor comprises first and second detectors for detecting partial or complete removal of the dispense interface, or partial or complete attachment of the dispense interface.

27. A medicament delivery device according to claim 26, wherein the first detector is activated when the dispense interface is partially attached to the attachment and the second detector is activated when the dispense interface is completely attached to the attachment.

28. A medicament delivery device according to claim 27, wherein the second detector is deactivated when the dispense interface is partially removed, and the first detector is deactivated when the dispense interface is completely removed from the attachment.

29. A method for controlling a medicament delivery device comprising a medicament cartridge retainer for holding a medicament cartridge, an attachment for attachment thereto of a dispense interface, the dispense interface for providing an exit pathway for the medicament contained in the cartridge, an interface sensor configured to provide an output indicative of whether the dispense interface is attached to the attachment, a piston rod for driving a bung of the medicament cartridge, a drive train for advancing the piston rod to the bung, and a controller configured to control operation of the device, wherein the controller is operative to sense stalling of the drive train, the method comprising:

sensing the output of the interface sensor;

determining whether the sensed output indicates whether the dispense interface is or is not at least partially attached to the attachment;

advancing the piston rod when the sensed output indicates that the dispense interface is not attached;

stopping or disabling advancement of the piston rod when the output of the interface sensor indicates that the dispense interface is at least partially attached; and

stopping the drive train when stalling of the drive train is sensed.

30. A method according to claim 29, comprising sensing stalling by sensing an output of an encoder provided in the drive train.