USING GAME THEORY IN IDENTIFYING COMPOUNDS THAT BIND TO TARGETS
First Claim
1. A method performed by one or more processing devices, comprising:
- retrieving information indicative of compounds and mutations of a target;
generating one or more predictions of binding affinities of the compounds to the mutations;
generating a simulation for introducing at least one of the compounds in response to at least one of the mutations;
identifying, based on an application of a game theory algorithm to the simulation and to the one or more predictions, an equilibrium of the simulation; and
identifying, from the equilibrium, a subset of the compounds with an increased binding affinity to the mutations relative to other binding affinities of other of the compounds.
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Accused Products
Abstract
A method performed by one or more processing devices includes retrieving information indicative of compounds and mutations of a target; generating one or more predictions of binding affinities of the compounds to the mutations; generating a simulation for introducing at least one of the compounds in response to at least one of the mutations; identifying, based on an application of a game theory algorithm to the simulation and to the one or more predictions, an equilibrium of the simulation; and identifying, from the equilibrium, a subset of the compounds with an increased binding affinity to the mutations relative to other binding affinities of other of the compounds.
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Citations
21 Claims
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1. A method performed by one or more processing devices, comprising:
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retrieving information indicative of compounds and mutations of a target; generating one or more predictions of binding affinities of the compounds to the mutations; generating a simulation for introducing at least one of the compounds in response to at least one of the mutations; identifying, based on an application of a game theory algorithm to the simulation and to the one or more predictions, an equilibrium of the simulation; and identifying, from the equilibrium, a subset of the compounds with an increased binding affinity to the mutations relative to other binding affinities of other of the compounds. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. One or more machine-readable media configured to store instructions that are executable by one or more processing devices to perform operations comprising:
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retrieving information indicative of compounds and mutations of a target; generating one or more predictions of binding affinities of the compounds to the mutations; generating a simulation for introducing at least one of the compounds in response to at least one of the mutations; identifying, based on an application of a game theory algorithm to the simulation and to the one or more predictions, an equilibrium of the simulation; and identifying, from the equilibrium, a subset of the compounds with an increased binding affinity to the mutations relative to other binding affinities of other of the compounds. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. An electronic system comprising:
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one or more processing devices; and one or more machine-readable media configured to store instructions that are executable by the one or more processing devices to perform operations comprising; retrieving information indicative of compounds and mutations of a target; generating one or more predictions of binding affinities of the compounds to the mutations; generating a simulation for introducing at least one of the compounds in response to at least one of the mutations; identifying, based on an application of a game theory algorithm to the simulation and to the one or more predictions, an equilibrium of the simulation; and identifying, from the equilibrium, a subset of the compounds with an increased binding affinity to the mutations relative to other binding affinities of other of the compounds. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification