REVASCULARIZATION DEVICES
3 Assignments
0 Petitions
Accused Products
Abstract
Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
24 Citations
46 Claims
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1-26. -26. (canceled)
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27. A revascularization device configured to restore flow within a cerebral artery having an occlusive thrombus, comprising:
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an elongate member having a proximal end and a distal end; a tubular scaffold having a proximal end and an open, non-filtering distal end, the scaffold comprising a plurality of cells, the proximal end of the scaffold being coupled to the distal end of the elongate member, the scaffold being adapted to radially self-expand from a non-expanded configuration within a catheter to an expanded configuration upon unsheathing of the scaffold from the catheter, the scaffold having a chronic outward force (COF) per unit length that does not decrease by more than 50% and is non-zero from a scaffold diameter of 1.5 mm to a scaffold diameter of 2.5 mm. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. An acute ischemic stroke revascularization device configured to address an occlusive thrombus within a cerebral artery, comprising:
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a flexible wire having a proximal end and a distal end, the flexible wire having sufficient flexibility to navigate tortuous vasculature to access a thrombus within a cerebral artery; a self-expandable, longitudinally-open scaffold comprising a plurality of cells and having a proximal end and an open, non-filtering distal end, the proximal end of the scaffold being coupled to the distal end of the flexible wire, the scaffold being adapted to radially self-expand from a non-expanded configuration within a catheter to an expanded configuration upon unsheathing of the scaffold from the catheter, the cells being sized and shaped to facilitate at least one of thrombus compression or thrombus engagement, the scaffold having a chronic outward force (COF) per unit length that does not decrease by more than 50% and is non-zero from a scaffold diameter of 1.5 mm to a scaffold diameter of 2.5 mm. - View Dependent Claims (39, 40, 41, 42)
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43. An acute ischemic stroke revascularization device configured to address an occlusive thrombus within a cerebral artery, comprising:
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an elongate member having a proximal end and a distal end, the elongate member having sufficient flexibility to navigate tortuous vasculature to access a thrombus within a blood vessel; a self-expandable, longitudinally-open scaffold comprising a plurality of cells and having a proximal end and an open, non-filtering distal end, the proximal end of the scaffold being coupled to the distal end of the elongate member, the scaffold having a chronic outward force (COF) per unit length that does not decrease by more than 50% and is non-zero from a scaffold diameter of 1.5 mm to a scaffold diameter of 2.5 mm. - View Dependent Claims (44, 45, 46)
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Specification