Anti-Complement C1s Antibodies and Uses Thereof
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Abstract
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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Citations
110 Claims
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1-80. -80. (canceled)
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81. A method of treating an individual having a complement-mediated disease or disorder, the method comprising administering to the individual a pharmaceutical composition comprising:
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a pharmaceutically acceptable excipient suitable for administration to a human; and an antibody that binds a complement C1s protein, wherein the antibody specifically binds an epitope within the complement C1s protein, wherein the antibody competes for binding the epitope with an antibody that comprises light chain CDRs of an antibody light chain variable region comprising amino acid sequence SEQ ID NO;
7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO;
8. - View Dependent Claims (82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96)
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97. A method of treating an individual having a complement-mediated disease or disorder, the method comprising administering to the individual a pharmaceutical composition comprising:
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a pharmaceutically acceptable excipient suitable for administration to a human; and an antibody that specifically binds a complement C1s protein, wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
8. - View Dependent Claims (98, 99, 100, 101, 102, 103)
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104. A method of treating an individual having a complement-mediated disease or disorder, the method comprising administering to the individual a pharmaceutical composition comprising:
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a pharmaceutically acceptable excipient suitable for administration to a human; and an antibody that specifically binds a complement C1s protein, wherein the antibody comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO;
7 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO;
8. - View Dependent Claims (105, 106, 107, 108, 109, 110)
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Specification