DIAGNOSTIC DEVICE
First Claim
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1. A diagnostic device, comprising:
- a first electrode made of a noble metal, which cannot be attacked by acid;
a second electrode having an electrode base made of silver and a layer of silver chloride covering said electrode base;
a container containing an acidic nutrient solution in which the first electrode and the second electrode are at least partially immersed, said container being adapted to allow introduction of a tissue sample into the acidic nutrient solution therein to expose said first and second electrodes to said acidic nutrient solution with said tissue sample therein;
a voltage source connected between said first electrode and said second electrode that produces an electric voltage across said first electrode and said second electrode in said acidic nutrient solution, with said tissue sample disposed therein, between said first and second electrodes;
an evaluation unit that detects a change in an electrical variable between said first electrode and said second electrode when ammonia is present in said acidic nutrient solution with said tissue sample disposed therein between said first electrode and said second electrode, said change resulting from said ammonia selectively attacking said silver chloride layer and exposing a portion of said base electrode made of silver; and
a results indicator in communication with said evaluation unit and configured to provide a visual indication as to the presence of a predetermined threshold amount of ammonia in said acidic nutrient solution with said tissue sample disposed therein.
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Abstract
A diagnostic device as a first electrode formed by a noble metal that is not attackable by acid, and a second electrode that is formed of silver. The first and second electrodes are at least partially immersed in a nutrient solution contained in a container, into which a tissue sample can be introduced. An electrical voltage is applied between the first and second electrodes, and a change in an electrical variable between the electrodes is measured when ammonia is present. The diagnostic device allows fast screening of tissue samples for Helicobacter pylori.
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Citations
22 Claims
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1. A diagnostic device, comprising:
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a first electrode made of a noble metal, which cannot be attacked by acid; a second electrode having an electrode base made of silver and a layer of silver chloride covering said electrode base; a container containing an acidic nutrient solution in which the first electrode and the second electrode are at least partially immersed, said container being adapted to allow introduction of a tissue sample into the acidic nutrient solution therein to expose said first and second electrodes to said acidic nutrient solution with said tissue sample therein; a voltage source connected between said first electrode and said second electrode that produces an electric voltage across said first electrode and said second electrode in said acidic nutrient solution, with said tissue sample disposed therein, between said first and second electrodes; an evaluation unit that detects a change in an electrical variable between said first electrode and said second electrode when ammonia is present in said acidic nutrient solution with said tissue sample disposed therein between said first electrode and said second electrode, said change resulting from said ammonia selectively attacking said silver chloride layer and exposing a portion of said base electrode made of silver; and a results indicator in communication with said evaluation unit and configured to provide a visual indication as to the presence of a predetermined threshold amount of ammonia in said acidic nutrient solution with said tissue sample disposed therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification
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Current AssigneeSiemens AG
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Original AssigneeSiemens AG
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InventorsKUTH, Rainer, FOERTSCH, Stefan, MAIER, Karl-Heinz
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Application NumberUS14/151,468Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current435/287.1CPC Class CodesC12Q 1/10 EnterobacteriaG01N 33/4833 of solid biological materia...
