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SYSTEMS AND METHODS FOR HEMODYNAMIC DETECTION OF CIRCULATORY ANOMALIES

  • US 20140128733A1
  • Filed: 12/09/2013
  • Published: 05/08/2014
  • Est. Priority Date: 07/15/2008
  • Status: Abandoned Application
First Claim
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1. A method for detecting and quantifying a right-to-left cardiac and/or pulmonary shunt in a mammalian body, comprising:

  • calculating the surface area of the body;

    calculating cardiac output using, among other things, the calculated surface area of the body;

    determining, as a function of time, the relative concentration of a fluorescing indicator introduced to and circulating within the blood stream of the body, by analyzing indicator fluorescence readings provided by a non-invasive sensor that is located along the skin surface of the body and both transcutaneously excites the indicator into fluorescence and transcutaneously detects said fluorescence;

    generating, using the determined indicator concentrations, an indicator dilution curve with a recirculation component excluded therefrom;

    calculating the area under a normal portion of the dilution curve;

    calculating the area under a premature peak in the dilution curve if such a peak exists;

    identifying the existence of a right-to-left shunt if the area under a premature peak in the dilution curve is determined to be non-zero; and

    if a shunt is identified, calculating the shunt flow rate (shunt conductance) by performing a ratiometric analysis of the area under the premature peak in the dilution curve to the area under the normal portion of the dilution curve, and multiplying the result of said analysis by the calculated cardiac output value.

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