DELIVERY OF LARGE MOLECULAR WEIGHT BIOLOGICALLY ACTIVE SUBSTANCES
First Claim
1. A device for photokinetic intradermal and/or transdermal delivery of a biologically active substance to a subject, said device comprising:
- (1) a generator that provides an oscillating electrical pulse;
(2) at least one light emitting diode that receives the oscillating electrical pulse and responds by providing an incoherent light; and
,(3) a donor cell that holds a formulation comprising the biologically active substance, wherein the donor cell is positioned to receive the incoherent light.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates generally to intradermal, transdermal, and/or transmembrane delivery of biologically active substances in the epidermis and/or through the skin, sub-dermal tissues, blood vessels and cellular membranes without causing damage to the cellular surface, tissue or membrane. The biologically active substances may have a molecular weight no less than about 5.8 kDa to about 2,500 kDa, such as Hyaluronic Acid (HA). The biologically active substances may be deposited in a dermal patch containing a red algae polysaccharide-based matrix, wherein the red algae polysaccharide is an extract of Chondrus crispus at 2% by weight of the dermal patch. The invention provides systems and methods for enhanced intradermal, transdermal, and/or transmembrane delivery of such biologically active substances using pulsed incoherent light. The invention further provides a device for the application of the pulsed incoherent light to cellular surfaces and membranes using those compositions and methods.
-
Citations
104 Claims
-
1. A device for photokinetic intradermal and/or transdermal delivery of a biologically active substance to a subject, said device comprising:
-
(1) a generator that provides an oscillating electrical pulse; (2) at least one light emitting diode that receives the oscillating electrical pulse and responds by providing an incoherent light; and
,(3) a donor cell that holds a formulation comprising the biologically active substance, wherein the donor cell is positioned to receive the incoherent light.
-
-
2-54. -54. (canceled)
-
55. A method for photokinetic intradermal and/or trans dermal delivery of a biologically active substance having a molecular weight of no less than 5800 Da to a subject, the method comprising:
-
(1) preparing a formulation comprising the biologically active substance; (2) applying said formulation to a cellular surface on the skin of the subject; (3) illuminating said formulation on said cellular surface with a pulsed incoherent light having a selected wavelength, pulse rate and duty cycle; and
,(4) allowing said biologically active substance in said formulation to permeate said cellular surface, thereby effecting photokinetic intradermal and/or transdermal delivery of the biologically active substance. - View Dependent Claims (62, 64, 73, 74, 75, 77, 84, 86, 87, 89, 90, 91, 92, 93, 94, 95, 96)
-
-
56-61. -61. (canceled)
-
63. (canceled)
-
65-72. -72. (canceled)
-
76. (canceled)
-
78-83. -83. (canceled)
-
85. (canceled)
-
88. (canceled)
-
97-101. -101. (canceled)
-
103. A method for photokinetic intradermal and/or transdennal delivery of a biologically active substance to a subject, the method comprising:
-
(1) preparing a dermal patch comprising the biologically active substance, wherein the dermal patch conlprises a red algae polysaccharide-based matrix, and wherein said red algae polysaccharide is an extract of Chondrus crispus at 2% by weight of the dermal patch; (2) applying said dermal patch to a cellular surface on the skin of the subject; (3) illuminating said dermal patch on said cellular surface with a pulsed incoherent light having a selected wavelength, pulse rate and duty cycle; and
,(4) allowing said biologically active substance in said dermal patch to permeate said cellular surface, thereby effecting photokinetic intradermal and/or transdermal delivery of the biologically active substance.
-
-
104-110. -110. (canceled)
Specification