DEFINITIVE ENDODERM
First Claim
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1. An in vitro cell culture comprising human definitive endoderm cells in a medium comprising serum, wherein less than about 5% (v/v) of the medium is serum.
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Abstract
Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
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Citations
20 Claims
- 1. An in vitro cell culture comprising human definitive endoderm cells in a medium comprising serum, wherein less than about 5% (v/v) of the medium is serum.
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19. An in vitro cell culture comprising human definitive endoderm cells in a medium comprising serum and a TGFβ
- superfamily growth factor, wherein less than about 5% (v/v) of the medium is serum.
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20. An in vitro cell culture comprising human definitive endoderm cells in a medium comprising serum, a TGFβ
- superfamily growth factor and a Wnt family member, wherein less than about 5% (v/v) of the medium is serum.
Specification