SELECTIVE SEROTONIN 2A/2C RECEPTOR INVERSE AGONISTS AS THERAPEUTICS FOR NEURODEGENERATIVE DISEASES
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Abstract
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson'"'"'s Disease, related human neurodegenerative diseases, and psychosis.
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121 Claims
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1-86. -86. (canceled)
- 87. A method for treating a neurodegenerative disease, or a symptom thereof, comprising administering to a patient suffering from a neurodegenerative disease, or a symptom thereof, a therapeutically effective amount of a compound of formula (I):
- 105. A method for treating psychosis secondary to a neurodegenerative disorder, comprising administering to a patient suffering from a neurodegenerative disorder, a therapeutically effective amount of a compound of formula (I):
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