PHOSPHORYLATED POLYOLS, PYROPHOSPHATES, AND DERIVATIVES THEREOF HAVING BIOLOGICAL ACTIVITY
First Claim
1. A method for treating a patient having a condition associated with PI3 kinase activity, comprising administering to the patient an effective amount of a PI3K inhibitor having a pyrophosphoryl ring, or structural mimetic thereof.
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Accused Products
Abstract
The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.
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Citations
18 Claims
- 1. A method for treating a patient having a condition associated with PI3 kinase activity, comprising administering to the patient an effective amount of a PI3K inhibitor having a pyrophosphoryl ring, or structural mimetic thereof.
- 15. A compound of the formula (II)
Specification