COMPOSITION AND METHOD FOR DELIVERY OF HYDROPHOBIC ACTIVE AGENTS
First Claim
1. A delivery composition for local administration of a hydrophobic active agent, the delivery composition comprising:
- a cationic delivery agent;
a therapeutically effective amount of the hydrophobic active agent; and
a pharmaceutically acceptable aqueous carrier.
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Accused Products
Abstract
Disclosed herein is a delivery composition for administering a hydrophobic active agent. In one embodiment, a delivery composition for local administration of a hydrophobic active agent to a tissue or organ of a patient is disclosed. In one embodiment, the delivery composition includes a cationic delivery agent, a therapeutically effective amount of a hydrophobic active agent and a pharmaceutically acceptable aqueous carrier. In one embodiment, the cationic delivery agent includes polyethyleneimine (PEI). In a more specific embodiment, the cationic delivery agent includes branched PEI. Methods of making the delivery composition, as well as kits and methods of use are also disclosed.
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Citations
64 Claims
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1. A delivery composition for local administration of a hydrophobic active agent, the delivery composition comprising:
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a cationic delivery agent; a therapeutically effective amount of the hydrophobic active agent; and a pharmaceutically acceptable aqueous carrier. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 15, 18, 19)
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6. (canceled)
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16-17. -17. (canceled)
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20-45. -45. (canceled)
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46. A method for local administration of a therapeutically or prophylactically effective amount of a hydrophobic active agent to a tissue or organ of a patient, the method comprising:
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preparing a composition comprising a cationic delivery agent; a therapeutically effective amount of the hydrophobic active agent; and a pharmaceutically acceptable aqueous carrier; and applying the composition to the tissue or organ of the patient. - View Dependent Claims (63, 64)
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47-62. -62. (canceled)
Specification